When metal-catalyzed C-H functionalization meets visible-light photocatalysis.

While aiming at sustainable organic synthesis, over the last decade particular attention has been focused on two modern fields, C-H bond activation, and visible-light-induced photocatalysis. Couplings through C-H bond activation involve the use of non-prefunctionalized substrates that are directly converted into more complex molecules, without the need of a previous functionalization, thus considerably reduce waste generation and a number of synthetic steps. In parallel, transformations involving photoredox catalysis promote radical reactions in the absence of radical initiators. They are conducted under particularly mild conditions while using the visible light as a cheap and economic energy source. In this way, these strategies follow the requirements of environment-friendly chemistry. Regarding intrinsic advantages as well as the complementary mode of action of the two catalytic transformations previously introduced, their merging in a synergistic dual catalytic system is extremely appealing. In that perspective, the scope of this review aims to present innovative reactions combining C-H activation and visible-light induced photocatalysis.