Epstein David, Kvanta Anders, Lindqvist Pelle G
a Karolinska Institutet , Stockholm , Sweden.
b St. Eriks Eye Hospital , Stockholm , Sweden.
Curr Eye Res. 2017 Mar;42(3):448-451. doi: 10.1080/02713683.2016.1188117. Epub 2016 Jun 27.
Central retinal vein occlusion (CRVO) has been shown to occur more often in winter/spring season. We aimed to evaluate if patients with CRVO have more vitamin D deficiency compared to matched controls.
Prospective match controlled study of 72 patients with CRVO and 144 matched controls. All new CRVO cases presenting at St. Erik Eye Hospital, Stockholm, Sweden during the study period were approached to participate. Statistics Sweden provided randomly selected controls matched for age, gender, and season. The first 18 cases of CRVO and 36 controls for each of the four seasons were included and blood was drawn for 25-OH vitamin D analysis (25(OH)D).
About half of the patients (51.4%) in the CRVO group had vitamin D deficiency [25(OH)D < 50 nmol/l] as compared to 39.3% in the control group [odds ratio 1.64, 95% confidence interval (CI) 0.91-2.94]. The mean concentrations of serum 25(OH)D were 55.3 nmol/l (95% CI 48.4-62.2) in the study group and 59.8 nmol/l (95% CI 55.4-64.2) in the control group (p = 0.28). In stratified analysis, the CRVO patients under 75 years had significantly lower 25(OH)D levels than the matched controls (47.8 nmol/l vs. 59.0 nmol/l, p = 0.02).
Vitamin D deficiency is common in patients with CRVO. No significant differences in vitamin deficiency or 25(OH)D levels were found in comparison to the control group. However, the CRVO patients under 75 years had significantly lower 25(OH)D levels as compared to the control group.
视网膜中央静脉阻塞（CRVO）在冬春季节更为常见。我们旨在评估与匹配的对照组相比，CRVO患者是否存在更多维生素D缺乏的情况。
对72例CRVO患者和144例匹配的对照组进行前瞻性匹配对照研究。研究期间，所有在瑞典斯德哥尔摩圣埃里克眼科医院就诊的新发CRVO病例均被邀请参与。瑞典统计局提供了按年龄、性别和季节随机选取的匹配对照组。纳入了前18例CRVO病例以及四个季节中每个季节的36例对照组，采集血液进行25-羟基维生素D分析（25(OH)D）。
CRVO组约一半患者（51.4%）存在维生素D缺乏[25(OH)D < 50 nmol/l]，而对照组为39.3%[比值比1.64，95%置信区间（CI）0.91 - 2.94]。研究组血清25(OH)D的平均浓度为55.3 nmol/l（95% CI 48.4 - 62.2），对照组为59.8 nmol/l（95% CI 55.4 - 64.2）（p = 0.28）。分层分析显示，75岁以下的CRVO患者25(OH)D水平显著低于匹配的对照组（47.8 nmol/l对59.0 nmol/l，p = 0.02）。
CRVO患者中维生素D缺乏较为常见。与对照组相比，维生素缺乏或25(OH)D水平无显著差异。然而，75岁以下的CRVO患者25(OH)D水平显著低于对照组。
