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新生儿维生素D与C反应蛋白之间的负相关关系

Inverse Correlation between Vitamin D and C-Reactive Protein in Newborns.

作者信息

Tao Rui-Xue, Zhou Qi-Fan, Xu Zhi-Wei, Hao Jia-Hu, Huang Kun, Mou Zhe, Jiang Xiao-Min, Tao Fang-Biao, Zhu Peng

机构信息

Department of Gynecology and Obstetrics, Hefei First People's Hospital, Hefei 230001, China.

Department of Maternal, Child & Adolescent Health, and Anhui Provincial Key Laboratory of Population Health & Aristogenics, Anhui Medical University, Hefei 230032, China.

出版信息

Nutrients. 2015 Nov 10;7(11):9218-28. doi: 10.3390/nu7115468.

DOI:10.3390/nu7115468
PMID:26569292
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4663596/
Abstract

Some studies suggested that adequate vitamin D might reduce inflammation in adults. However, little is known about this association in early life. We aimed to determine the relationship between cord blood 25-hydroxyvitamin D (25(OH)D) and C-reactive protein (CRP) in neonates. Cord blood levels of 25(OH)D and CRP were measured in 1491 neonates in Hefei, China. Potential confounders including maternal sociodemographic characteristics, perinatal health status, lifestyle, and birth outcomes were prospectively collected. The average values of cord blood 25(OH)D and CRP were 39.43 nmol/L (SD = 20.35) and 6.71 mg/L (SD = 3.07), respectively. Stratified by 25(OH)D levels, per 10 nmol/L increase in 25(OH)D, CRP decreased by 1.42 mg/L (95% CI: 0.90, 1.95) among neonates with 25(OH)D <25.0 nmol/L, and decreased by 0.49 mg/L (95% CI: 0.17, 0.80) among neonates with 25(OH)D between 25.0 nmol/L and 49.9 nmol/L, after adjusting for potential confounders. However, no significant association between 25(OH)D and CRP was observed among neonates with 25(OH)D ≥50 nmol/L. Cord blood 25(OH)D and CRP levels showed a significant seasonal trend with lower 25(OH)D and higher CRP during winter-spring than summer-autumn. Stratified by season, a significant linear association of 25(OH)D with CRP was observed in neonates born in winter-spring (adjusted β = -0.11, 95% CI: -0.13, -0.10), but not summer-autumn. Among neonates born in winter-spring, neonates with 25(OH)D <25 nmol/L had higher risk of CRP ≥10 mg/L (adjusted OR = 3.06, 95% CI: 2.00, 4.69), compared to neonates with 25(OH)D ≥25 nmol/L. Neonates with vitamin D deficiency had higher risk of exposure to elevated inflammation at birth.

摘要

一些研究表明，充足的维生素D可能会减轻成年人的炎症。然而，关于生命早期的这种关联却知之甚少。我们旨在确定新生儿脐带血25-羟基维生素D（25(OH)D）与C反应蛋白（CRP）之间的关系。在中国合肥的1491名新生儿中测量了脐带血25(OH)D和CRP水平。前瞻性收集了包括母亲社会人口学特征、围产期健康状况、生活方式和出生结局等潜在混杂因素。脐带血25(OH)D和CRP的平均值分别为39.43 nmol/L（标准差=20.35）和6.71 mg/L（标准差=3.07）。按25(OH)D水平分层，在调整潜在混杂因素后，25(OH)D<25.0 nmol/L的新生儿中，25(OH)D每增加10 nmol/L，CRP降低1.42 mg/L（95%可信区间：0.90，1.95）；25(OH)D在25.0 nmol/L至49.9 nmol/L之间的新生儿中，CRP降低0.49 mg/L（95%可信区间：0.17，0.80）。然而，在25(OH)D≥50 nmol/L的新生儿中未观察到25(OH)D与CRP之间存在显著关联。脐带血25(OH)D和CRP水平呈现出显著的季节性趋势，冬春季节25(OH)D较低而CRP较高，高于夏秋季节。按季节分层，在冬春季节出生的新生儿中观察到25(OH)D与CRP存在显著线性关联（调整后β=-0.11，95%可信区间：-0.13，-0.10），但夏秋季节未观察到。在冬春季节出生的新生儿中，25(OH)D<25 nmol/L的新生儿CRP≥10 mg/L的风险较高（调整后比值比=3.06，95%可信区间：2.00，4.69），而25(OH)D≥25 nmol/L的新生儿则较低。维生素D缺乏的新生儿在出生时暴露于炎症升高的风险较高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5206/4663596/10a326500eca/nutrients-07-05468-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5206/4663596/acd7ec0d3931/nutrients-07-05468-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5206/4663596/ac272bcecbbb/nutrients-07-05468-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5206/4663596/d59a3ad4df45/nutrients-07-05468-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5206/4663596/10a326500eca/nutrients-07-05468-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5206/4663596/acd7ec0d3931/nutrients-07-05468-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5206/4663596/ac272bcecbbb/nutrients-07-05468-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5206/4663596/d59a3ad4df45/nutrients-07-05468-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5206/4663596/10a326500eca/nutrients-07-05468-g004.jpg

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