Wollenhaupt H J, Krech T, Schneider C, Zeidler H
Department of Endocrinology and Rheumatology, University Hospital, FRG.
Z Rheumatol. 1989 Mar-Apr;48(2):86-8.
A cohort analytic study was performed to investigate serum IgA-class antibodies against Chlamydia in 24 patients with chlamydial-induced arthritis (CIA). IgA-class antibodies against chlamydial antigens were positive (titre greater than or equal to 1:16) in 23 of the 24 IgG-positive CIA-patients (96%) in contrast to 16 of 40 patients (40%) with other rheumatic diseases (ankylosing spondylitis n = 6; undifferentiated arthritis n = 11; rheumatoid arthritis n = 12; degenerative joint disease n = 11), also positive for IgG-class chlamydial antibodies. Both the presence of specific IgA-antibodies and their geometric mean titre (1:28 vs. 1:4) differed significantly (p less than 0.001) between the two groups.
进行了一项队列分析研究，以调查24例衣原体诱导性关节炎（CIA）患者血清中抗衣原体的IgA类抗体。24例IgG阳性的CIA患者中有23例（96%）抗衣原体抗原的IgA类抗体呈阳性（滴度大于或等于1:16），相比之下，40例其他风湿性疾病患者（强直性脊柱炎n = 6；未分化关节炎n = 11；类风湿性关节炎n = 12；退行性关节病n = 11）中，同样IgG类衣原体抗体呈阳性的患者有16例（40%）。两组之间特异性IgA抗体的存在及其几何平均滴度（1:28对1:4）差异均有统计学意义（p<0.001）。
