Kasamatsu T, Sugase M, Yoshikawa H, Kawana T, Mizuno M
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo.
Nihon Sanka Fujinka Gakkai Zasshi. 1989 Apr;41(4):479-86.
Chlamydia trachomatis IgA and IgG antibody titers were determined by indirect immunoperoxidase assay in sera of 88 female patients with C. trachomatis-positive cervicitis and 55 C. trachomatis negative healthy controls. Serial serum samples obtained until 66 weeks after treatment were also studied for IgA and IgG antibodies in 28 of the 88 patients with chlamydial cervicitis. In the 88 patients, the presence (94.3%) of antibody (titer greater than or equal to 16) was comparable to that (100%) of IgG antibody (titer greater than or equal to 32), but in healthy controls the presence (5.4%) of IgA antibody was lower than that (30.6%) of IgG antibody. Serum IgA antibody decreased gradually and was undetectable (titer less than or equal to 8) at 20 weeks after treatment in 78.6% of the 28 patients. Serum IgG antibody persisted at stable levels within the same period. These data suggest that the presence of serum IgA antibody to C. trachomatis is correlated with active C. trachomatis infection of the female genital tract.
采用间接免疫过氧化物酶法检测了88例沙眼衣原体阳性宫颈炎女性患者及55例沙眼衣原体阴性健康对照者血清中的沙眼衣原体IgA和IgG抗体滴度。对88例衣原体宫颈炎患者中的28例患者治疗后直至66周期间采集的系列血清样本也进行了IgA和IgG抗体研究。在88例患者中，抗体（滴度大于或等于16）的阳性率（94.3%）与IgG抗体（滴度大于或等于32）的阳性率（100%）相当，但在健康对照者中，IgA抗体的阳性率（5.4%）低于IgG抗体的阳性率（30.6%）。在28例患者中，78.6%的患者血清IgA抗体在治疗后20周逐渐下降且检测不到（滴度小于或等于8）。同期血清IgG抗体维持在稳定水平。这些数据表明，血清沙眼衣原体IgA抗体的存在与女性生殖道沙眼衣原体的活动性感染相关。
