Apt Werner, Arribada Arturo, Zulantay Inés, Saavedra Miguel, Muñoz Catalina, Toro Bruno, Vega Bastián, Rodríguez Jorge
Laboratorio de Parasitología Básico-Clínico, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Clínica INDISA, Santiago, Chile.
Acta Trop. 2016 Oct;162:155-166. doi: 10.1016/j.actatropica.2016.06.025. Epub 2016 Jun 25.
Currently there are no biological markers to indicate which individuals with chronic indeterminate period of Chagas disease develop heart disease and who will remain all his life in this phase. The aim of this survey was to determine if Trypanosoma cruzi burden is related to the presence of heart disease in patients with chronic Chagas disease. 200 patients who had not been treated, 100 with cardiopathy and 100 without, groups A and B respectively, were submitted to clinical study and electrocardiogram, Echo-Doppler was performed for group A in which all important known causes of cardiopathy were discarded. In both groups xenodiagnosis, conventional PCR and quantitative PCR were undertaken. The 100 cardiopaths had 133 electrocardiographic alterations most of them in grade II of the New York Heart Association classification. 98 cardiopaths were classified in grade I by Echo-Doppler and only 2 cases were in grade III due to low ejection fraction. The difference in average parasitemia in patients of group A and B was not significant and no statistically differences were observed between average parasitemia of cardiopaths grade II versus grade I of NYHA. This results allow to characterize same clinical, electrocardiographical and parasitological features in chagasic cardiopaths of Chile.
目前，尚无生物学标志物可指示哪些患有慢性查加斯病不确定期的个体将会发展为心脏病，哪些个体将终生处于该阶段。本调查的目的是确定克氏锥虫负荷是否与慢性查加斯病患者心脏病的存在有关。200名未接受治疗的患者，分别为A组（100名患有心脏病）和B组（100名未患心脏病），接受了临床研究和心电图检查，对A组进行了超声心动图-多普勒检查，排除了所有已知的重要心脏病病因。两组均进行了异种诊断、常规PCR和定量PCR。100名心脏病患者有133处心电图改变，其中大多数属于纽约心脏协会分类的II级。98名心脏病患者经超声心动图-多普勒检查分类为I级，仅有2例因射血分数低而被分类为III级。A组和B组患者的平均寄生虫血症差异不显著，纽约心脏协会II级与I级心脏病患者的平均寄生虫血症之间未观察到统计学差异。这些结果有助于描述智利恰加斯心脏病患者的一些临床、心电图和寄生虫学特征。
