Lee Seonjoo, Habeck Christian, Razlighi Qolamreza, Salthouse Timothy, Stern Yaakov
Division of Biostatistics, New York State Psychiatric Institute, New York, NY, USA; Department of Psychiatry, Columbia University, New York, NY, USA.
Division of Cognitive Neuroscience, Department of Neurology, Columbia University, New York, NY, USA.
Neuroimage. 2016 Nov 15;142:293-300. doi: 10.1016/j.neuroimage.2016.06.041. Epub 2016 Jun 25.
A previous study of reference abilities and cortical thickness reported that association between reference abilities and cortical thickness summarized over large ROIs suppressed was suppressed after controlling for mean cortical thickness and global cognition. In this manuscript, we showed that preserving detailed spatial patterns of cortical thickness can identify reference-ability-specific association besides the association explained by global cognition and mean cortical thickness. We identified associations between cortical thickness and 3 cognitive reference abilities after controlling for mean thickness, global cognition, and linear chronological age: (1) memory, (2) perceptual speed, and (3) vocabulary. Global cognition was correlated with mean overall thickness but also was found to have a regionally specific pattern of associations. Nonlinear associations between cortical thickness and cognition were not observed, neither were nonlinear age effects. Age-by-thickness interactions were also absent. This implies that all thickness-cognition relations and age associations are independent of age and that consequently no age range is inherently special, since brain-behavioral findings are invariant across the whole age range.
先前一项关于参照能力与皮质厚度的研究报告称，在控制平均皮质厚度和整体认知后，大的受抑制感兴趣区（ROI）上汇总的参照能力与皮质厚度之间的关联被抑制。在本论文中，我们表明，除了由整体认知和平均皮质厚度所解释的关联外，保留皮质厚度的详细空间模式能够识别特定于参照能力的关联。在控制平均厚度、整体认知和线性实足年龄后，我们确定了皮质厚度与3种认知参照能力之间的关联：（1）记忆；（２）知觉速度；（3）词汇。整体认知与平均总厚度相关，但也发现具有区域特异性的关联模式。未观察到皮质厚度与认知之间的非线性关联，也未观察到非线性年龄效应。年龄与厚度的交互作用也不存在。这意味着所有厚度与认知的关系以及年龄关联均与年龄无关，因此不存在固有特殊的年龄范围，因为脑行为研究结果在整个年龄范围内是不变的。
