Nogo-A/B和Nogo-B受体表达在恶性黑色素瘤中的预后意义——一项初步研究

Prognostic Significance of NOGO-A/B and NOGO-B Receptor Expression in Malignant Melanoma - A Preliminary Study.

作者信息

Calik Jacek, Pula Bartosz, Piotrowska Aleksandra, Wojnar Andrzej, Witkiewicz Wojciech, Grzegrzolka Jedrzej, Podhorska-Okolow Marzena, Dziegiel Piotr

机构信息

Department of Chemotherapy, Lower Silesian Oncology Center, Wroclaw, Poland.

Department of Histology and Embryology, Medical University, Wroclaw, Poland Research and Development Center, Regional Specialist Hospital, Wroclaw, Poland.

出版信息

Anticancer Res. 2016 Jul;36(7):3401-7.

PMID:27354599

Abstract

BACKGROUND

Neurite outgrowth inhibitor type B (NOGO-B) and its receptor (NGBR) were shown to regulate various crucial cellular processes and may be therefore potential factors influencing carcinogenesis.

MATERIALS AND METHODS

Expression of NOGO-A, NOGO-A/B and NGBR was studied in benign melanocytic lesions and primary tumors and metastases of malignant melanoma (MM).

RESULTS

Cytoplasmic expression of the studied antigens was detected in melanocytes and MM cells. NOGO-A/B expression was significantly lower in metastatatic MM cases compared to primary MM tumors (p<0.01) and bening melanocytic lesions (p<0.001). In primary MM tumors, NOGO-A expression intensity positively correlated with NOGO-A/B (r=0.32, p<0.05) and NGBR expression (r=0.53, p<0.0001). NOGO-B and NGBR immunoreactivity correlated negatively with depth of primary MM infiltration (both p<0.01). Moreover, low NOGO-A/B expression was a factor of poor prognosis of primary MM.

CONCLUSION

NOGO-A/B may be a negative prognostic factor of MM.

摘要

背景

B型神经突生长抑制因子（NOGO-B）及其受体（NGBR）已被证明可调节各种关键的细胞过程，因此可能是影响致癌作用的潜在因素。

材料与方法

研究了NOGO-A、NOGO-A/B和NGBR在良性黑素细胞病变以及恶性黑色素瘤（MM）的原发性肿瘤和转移灶中的表达情况。

结果

在所研究的抗原的细胞质表达在黑素细胞和MM细胞中被检测到。与原发性MM肿瘤（p<0.01）和良性黑素细胞病变（p<0.001）相比，转移性MM病例中NOGO-A/B的表达显著降低。在原发性MM肿瘤中，NOGO-A的表达强度与NOGO-A/B（r=0.32，p<0.05）和NGBR的表达（r=0.53，p<0.0001）呈正相关。NOGO-B和NGBR的免疫反应性与原发性MM浸润深度呈负相关（均p<0.01）。此外，低NOGO-A/B表达是原发性MM预后不良的一个因素。