The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Obesity (Silver Spring). 2016 Aug;24(8):1759-66. doi: 10.1002/oby.21547. Epub 2016 Jun 29.
The associations of maternal plasma n-3 and n-6 polyunsaturated fatty acid (PUFA) concentrations during pregnancy with infant subcutaneous fat were examined.
In a population-based prospective cohort study among 904 mothers and their infants, maternal plasma n-3 and n-6 PUFA concentrations were measured at midpregnancy. Body mass index, total subcutaneous fat, and central-to-total subcutaneous fat ratio were calculated at 1.5, 6, and 24 months.
Maternal n-3 PUFA levels were not consistently associated with infant body mass index or total subcutaneous fat. Higher maternal total n-3 PUFA levels, and specifically eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid, were associated with higher central-to-total subcutaneous fat ratio at 1.5 months, whereas higher maternal total n-3 PUFA levels were associated with lower central-to-total subcutaneous fat ratio at 6 months (all P values < 0.05). These associations were not present at 24 months. Maternal n-6 PUFA levels were not consistently associated with infant subcutaneous fat. A higher n-6/n-3 ratio was associated with lower central-to-total subcutaneous fat ratio at 1.5 months only (P value < 0.05).
Maternal n-3 PUFA levels during pregnancy may have transient effects on infant subcutaneous fat. Further studies are needed to assess the effects of maternal PUFA concentrations on fat mass development during early infancy.
探讨妊娠期间母体血浆 n-3 和 n-6 多不饱和脂肪酸（PUFA）浓度与婴儿皮下脂肪的关系。
在一项基于人群的前瞻性队列研究中，对 904 名母亲及其婴儿进行了研究，在妊娠中期测量了母体血浆 n-3 和 n-6 PUFA 浓度。在 1.5、6 和 24 个月时计算了体重指数、总皮下脂肪和中心-总皮下脂肪比。
母体 n-3 PUFA 水平与婴儿的体重指数或总皮下脂肪无一致性关联。母体总 n-3 PUFA 水平较高，特别是二十碳五烯酸、二十二碳五烯酸和二十二碳六烯酸，与 1.5 个月时的中心-总皮下脂肪比较高相关，而母体总 n-3 PUFA 水平较高与 6 个月时的中心-总皮下脂肪比较低相关（所有 P 值均<0.05）。这些关联在 24 个月时不存在。母体 n-6 PUFA 水平与婴儿皮下脂肪无一致性关联。n-6/n-3 比值较高仅与 1.5 个月时的中心-总皮下脂肪比较低相关（P 值<0.05）。
妊娠期间母体 n-3 PUFA 水平可能对婴儿皮下脂肪有短暂影响。需要进一步研究评估母体 PUFA 浓度对婴儿早期脂肪量发育的影响。
