Bychkov V A, Nikitina E G, Ibragimova M K, Kaigorodova E V, Choinzonov E L, Litviakov N V
Tomsk Cancer Research Institute, Tomsk 634050, Russian Federation.
Siberian State Medical University, Tomsk 634050, Russian Federation.
Exp Oncol. 2016 Jun;38(2):68-72.
An etiological role of high risk human papillomavirus (HPV) in the development of cervical cancer has been well established. Hence, attention of researchers has been focused on the role of HPV in pathogenesis of other malignancies, such as head and neck cancers. An analysis of epidemiological data on the prevalence of HPV infection among healthy people and patients with precancerous lesions and/or cancer is an important step in understanding the role of HPV in head and neck carcinogenesis. More and more data de-monstrate the impact of HPV infection on disease outcome. HPV-positive patients have been shown to have better responses to radiotherapy and better overall and disease-free survival than HPV-negative patients. This review presents data of the meta-analysis based on a large number of original studies on HPV prevalence in patients with precancerous lesions and in patients with oral, oropharyngeal and laryngeal cancers as well as findings on the impact of HPV infection on survival of these patients.
高危型人乳头瘤病毒（HPV）在宫颈癌发生中的病因学作用已得到充分证实。因此，研究人员的注意力集中在HPV在其他恶性肿瘤（如头颈癌）发病机制中的作用。分析健康人群、癌前病变患者和/或癌症患者中HPV感染率的流行病学数据，是了解HPV在头颈癌发生中作用的重要一步。越来越多的数据表明HPV感染对疾病转归有影响。与HPV阴性患者相比，HPV阳性患者对放疗的反应更好，总生存期和无病生存期也更好。本综述基于大量关于癌前病变患者、口腔癌、口咽癌和喉癌患者中HPV感染率的原始研究，呈现了荟萃分析的数据，以及HPV感染对这些患者生存影响的研究结果。
