Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia.
National Research Tomsk State University, Tomsk, Russia.
Med Oncol. 2018 Sep 5;35(11):140. doi: 10.1007/s12032-018-1201-9.
The involvement of human papillomavirus in carcinogenesis of colorectal cancer is a contentious issue. The presented meta-analysis was performed to systematize the currently available research results on the matter. The analysis was based on the data from 19 studies to assess the association of HPV infection with colorectal cancer. According to the obtained data, researchers determined the statistically significant level of HPV infection in tumor tissue of CRC and the resulting relative risk of developing CRC with HPV infection to be RR (95% CI) = 2.97 (1.42-6.22) with p = 0.0039.
人乳头瘤病毒（HPV）在结直肠癌的致癌作用是一个有争议的问题。本荟萃分析旨在系统地整理目前关于这一问题的研究结果。该分析基于 19 项研究的数据，评估 HPV 感染与结直肠癌的相关性。根据获得的数据，研究人员确定了 HPV 感染在 CRC 肿瘤组织中的统计学显著水平，以及 HPV 感染导致 CRC 的相对风险 RR（95%CI）为 2.97（1.42-6.22），p=0.0039。
