Zhu H-Y, Gao Y-C, Wang Y, Zhang C-Q
Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, China.
Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, China
Bone Joint Res. 2016 Jun;5(6):276-9. doi: 10.1302/2046-3758.56.BJR-2015-0014.R1.
Circulating exosomes represent novel biomarkers for multiple diseases. In this study, we investigated whether circulating exosome levels could be used as a diagnostic biomarker for steroid-induced osteonecrosis of the femoral head (ONFH).
We assessed the serum exosome level of 85 patients with steroid-induced ONFH and 115 healthy donors by Nanosight detection. We then assessed the diagnostic accuracy of serum exosomes by receiver operating characteristic curve analysis.
The circulating exosome level of the ONFH group was significantly lower than that of control group. The area under the curve was 0.72, suggesting that the level of serum exosomes has moderate diagnostic accuracy for steroid-induced ONFH.
Circulating exosome levels are valuable in the diagnosis of steroid-induced ONFH.Cite this article: H-Y. Zhu, Y-C. Gao, Y. Wang, C-Q. Zhang. Circulating exosome levels in the diagnosis of steroid-induced osteonecrosis of the femoral head. Bone Joint Res 2016;5:276-279. DOI: 10.1302/2046-3758.56.BJR-2015-0014.R1.
循环外泌体是多种疾病的新型生物标志物。在本研究中，我们调查了循环外泌体水平是否可作为类固醇诱导的股骨头坏死（ONFH）的诊断生物标志物。
我们通过纳米可视检测评估了85例类固醇诱导的ONFH患者和115例健康供体的血清外泌体水平。然后通过受试者工作特征曲线分析评估血清外泌体的诊断准确性。
ONFH组的循环外泌体水平显著低于对照组。曲线下面积为0.72，表明血清外泌体水平对类固醇诱导的ONFH具有中等诊断准确性。
循环外泌体水平在类固醇诱导的ONFH诊断中具有重要价值。引用本文：朱H-Y，高Y-C，王Y，张C-Q。循环外泌体水平在类固醇诱导的股骨头坏死诊断中的应用。骨关节研究2016；5：276 - 279。DOI：10.1302/2046 - 3758.56.BJR - 2015 - 0014.R1。
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