Lee Eunee, Rhim Issac, Lee Jong Won, Ghim Jeong-Wook, Lee Seungjoon, Kim Eunjoon, Jung Min Whan
Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon, 305-701 Korea, and.
Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon, 305-701 Korea, and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 305-701 Korea.
J Neurosci. 2016 Jun 29;36(26):6926-36. doi: 10.1523/JNEUROSCI.0307-16.2016.
Although the medial prefrontal cortex (mPFC) is known to play a crucial role in rodent social behavior, little is known about mPFC neural correlates of social behavior. In the present study, we examined single-neuron activity in the mPFC of mice performing a modified version of the three-chamber test. We found that a subset of mPFC neurons elevate discharge rates when approaching a stranger mouse but not when approaching an inanimate object or an empty chamber. Our results reveal mPFC neural activity that is correlated with social approach behavior in a widely used social-interaction paradigm. These findings might be helpful for future investigations of mPFC neural processes underlying social interaction in health and disease.
Although the prefrontal cortex is known to play a crucial role in rodent social behavior, little is known about prefrontal neural correlates of social behavior. This study shows that the activity of a subset of prefrontal neurons increases in association with social approach behavior during a three-chamber test-a widely used behavioral paradigm. Such responses might be a signature of prefrontal neural processes underlying social approach behavior.
尽管已知内侧前额叶皮质（mPFC）在啮齿动物社交行为中起关键作用，但对社交行为的mPFC神经关联了解甚少。在本研究中，我们检测了进行改良版三室试验的小鼠mPFC中的单神经元活动。我们发现，mPFC的一部分神经元在接近陌生小鼠时放电率升高，但在接近无生命物体或空室时则不然。我们的结果揭示了在广泛使用的社交互动范式中与社交接近行为相关的mPFC神经活动。这些发现可能有助于未来对健康和疾病状态下社交互动背后的mPFC神经过程的研究。
尽管已知前额叶皮质在啮齿动物社交行为中起关键作用，但对社交行为的前额叶神经关联了解甚少。本研究表明，在三室试验（一种广泛使用的行为范式）中，一部分前额叶神经元的活动会随着社交接近行为而增加。这种反应可能是社交接近行为背后前额叶神经过程的一个标志。
