Lippert Frank
Department of Cariology, Operative Dentistry and Dental Public Health, Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, Ind., USA.
Caries Res. 2016;50(4):378-82. doi: 10.1159/000446849. Epub 2016 Jul 1.
Two mechanistic, laboratory, factorial design studies were conducted to investigate the effect of the stannous ion (Sn2+) in the absence or presence of fluoride on caries lesion de- and remineralization. Study I was concerned with determining changes in mineral distribution of subsurface lesions, whereas study II investigated changes in surface hardness of surface-softened lesions as a function of pH. Study I showed that Sn2+ modulates the effects of fluoride by preventing lamination. Study II revealed that the effect of Sn2+ on rehardening is pH dependent. Neither study demonstrated synergy between Sn2+ and fluoride, yet interactions were observed. Sn2+ does interfere with remineralization to some extent although it provided acid resistance. The role of Sn2+ in the caries process is complex.
进行了两项机械性、实验室因素设计研究，以调查在有或没有氟化物存在的情况下，亚锡离子（Sn2+）对龋损脱矿和再矿化的影响。研究I关注确定表层下病变矿物质分布的变化，而研究II则研究表面软化病变的表面硬度随pH值变化的情况。研究I表明，Sn2+通过防止分层来调节氟化物的作用。研究II显示，Sn2+对再硬化的影响取决于pH值。两项研究均未证明Sn2+与氟化物之间存在协同作用，但观察到了相互作用。尽管Sn2+提供了抗酸性，但它在一定程度上确实会干扰再矿化。Sn2+在龋病过程中的作用很复杂。
