Berg K, Bommer J C, Moan J
Institute for Cancer Research, Department of Biophysics, Montebello, Oslo, Norway.
Cancer Lett. 1989 Jan;44(1):7-15. doi: 10.1016/0304-3835(89)90101-8.
Cellular uptake of aluminum phthalocyanine sulfonated to different degree was studied by means of fluorescence measurements and HPLC chromatography. These results were correlated to the lipophilic property of each drug measured as the distribution of the drug between a lipophilic phase (Triton X-114) and an aqueous phase. All the sulfonated aluminum phthalocyanines were taken up into cells to a higher extent than porphyrins of a similar lipophilicity. The cellular uptake of monosulfonated aluminum phthalocyanine was 10-fold higher than the cellular uptake of tetrasulfonated aluminum phthalocyanine and at least 50% higher than tetra(3-hydroxy-phenyl)porphin which is so far the porphyrin shown to be taken up into cells to the highest extent.
通过荧光测量和高效液相色谱法研究了不同磺化程度的铝酞菁的细胞摄取情况。这些结果与每种药物的亲脂性相关，亲脂性通过药物在亲脂相（曲拉通X-114）和水相之间的分布来衡量。所有磺化铝酞菁的细胞摄取程度均高于具有相似亲脂性的卟啉。单磺化铝酞菁的细胞摄取量比四磺化铝酞菁高10倍，比四（3-羟基苯基）卟吩至少高50%，四（3-羟基苯基）卟吩是迄今为止显示细胞摄取程度最高的卟啉。
