用于光化学疗法的磺化铝酞菁的评估。光灭活相对效率的研究。

Evaluation of sulfonated aluminum phthalocyanines for use in photochemotherapy. A study on the relative efficiencies of photoinactivation.

作者信息

Berg K, Bommer J C, Moan J

出版信息

Photochem Photobiol. 1989 May;49(5):587-94. doi: 10.1111/j.1751-1097.1989.tb08428.x.

DOI:10.1111/j.1751-1097.1989.tb08428.x

Abstract

The cellular photosensitivity caused by aluminum phthalocyanines sulfonated to different degrees (AlPcSn) has been investigated. The phototoxic effect increased with decreasing number of sulfonate groups on the macrocycle, with the exception of AlPcS1 which was less phototoxic than AlPcS2 but more phototoxic than AlPcS3 and AlPcS4. The tendency of the AlPcSns to aggregate in our cellular system increased with increasing lipophilicity of the sensitizers. The aggregates had little or no photosensitizing activity. The low efficiency of cell inactivation caused by AlPcS1 can be explained by the highly aggregated state of this sensitizer in the cells. AlPcS2 and AlPcS3 induced a lower degree of cell inactivation per fluorescing quantum and per quantum absorbed by monomeric species than did AlPcS2 and AlPcS1. AlPcS4 and AlPcS3 are therefore suggested to be in different intracellular locations than AlPcS2 and AlPcS1.

摘要

对不同磺化程度的磺化铝酞菁（AlPcSn）所引起的细胞光敏性进行了研究。除了AlPcS1的光毒性比AlPcS2小但比AlPcS3和AlPcS4大之外，光毒性效应随着大环上磺酸根基团数量的减少而增强。在我们的细胞体系中，AlPcSn的聚集倾向随着敏化剂亲脂性的增加而增强。聚集体几乎没有或没有光敏活性。AlPcS1导致细胞失活效率低可以用该敏化剂在细胞中的高度聚集状态来解释。与AlPcS2和AlPcS1相比，AlPcS2和AlPcS3每荧光量子以及每被单体物种吸收的量子所诱导的细胞失活程度更低。因此，有人提出AlPcS4和AlPcS3与AlPcS2和AlPcS1在细胞内的位置不同。