Colombo John, Gustafson Kathleen M, Gajewski Byron J, Shaddy D Jill, Kerling Elizabeth H, Thodosoff Jocelynn M, Doty Tasha, Brez Caitlin C, Carlson Susan E
Department of Psychology, Schiefelbusch Institute for Life Span Studies, University of Kansas, Lawrence, Kansas.
Department of Neurology, University of Kansas Medical Center, Lawrence, Kansas.
Pediatr Res. 2016 Nov;80(5):656-662. doi: 10.1038/pr.2016.134. Epub 2016 Jun 30.
Results of randomized trials on the effects of prenatal docosahexaenoic acid (DHA) on infant cognition are mixed, but most trials have used global standardized outcomes, which may not be sensitive to effects of DHA on specific cognitive domains.
Women were randomized to 600 mg/d DHA or a placebo for the last two trimesters of pregnancy. Infants of these mothers were then followed on tests of visual habituation at 4, 6, and 9 mo of age.
DHA supplementation did not affect look duration or habituation parameters but infants of supplemented mothers maintained high levels of sustained attention (SA) across the first year; SA declined for the placebo group. The supplemented group also showed significantly reduced attrition on habituation tasks, especially at 6 and 9 mo.
The findings support with the suggestion that prenatal DHA may positively affect infants' attention and regulation of state.
关于产前补充二十二碳六烯酸（DHA）对婴儿认知影响的随机试验结果不一，但大多数试验使用的是整体标准化结果，这可能对DHA对特定认知领域的影响不敏感。
在妊娠最后两个阶段，将女性随机分为每日补充600毫克DHA组或安慰剂组。然后对这些母亲的婴儿在4个月、6个月和9个月大时进行视觉习惯化测试。
补充DHA并未影响注视持续时间或习惯化参数，但补充DHA母亲的婴儿在第一年中保持了较高水平的持续注意力（SA）；安慰剂组的SA下降。补充组在习惯化任务中的损耗也显著减少，尤其是在6个月和9个月时。
这些发现支持产前DHA可能对婴儿注意力和状态调节产生积极影响的观点。
