Wang Zilong, Li Dandan, Zhou Guoyi, Xu Zhen, Wang Xinkun, Tan Senbao, Li Zhenghao, Li Xiaoli, Song Changze, Yuan Song
Department of Andrology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Department of Burns and Plastic Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Front Endocrinol (Lausanne). 2025 May 21;16:1505213. doi: 10.3389/fendo.2025.1505213. eCollection 2025.
Asthenozoospermia is a severe condition characterized by abnormal sperm motility, contributing to 50% of male infertility cases. Idiopathic asthenozoospermia refers to a form of this condition with no identifiable causes through routine clinical examinations, potentially linked to apoptosis and oxidative stress induced by excessive reactive oxygen species (ROS). At low concentrations, ROS positively influence physiological processes, including sperm mature and motility. However, elevated ROS levels can harm human spermatozoa through oxidative stress, primarily due to the absence of effective DNA damage repair mechanisms and inadequate antioxidant defenses. In this review, we summarize the physiological and pathophysiological roles, endogenous and exogenous sources, and therapeutic strategies related to ROS in idiopathic asthenozoospermia. Ultimately, maintaining a proper balance between ROS concentrations and antioxidants is crucial for ensuring male reproductive health.
弱精子症是一种以精子活力异常为特征的严重病症，占男性不育病例的50%。特发性弱精子症是指通过常规临床检查无法确定病因的这种病症形式，可能与过量活性氧（ROS）诱导的细胞凋亡和氧化应激有关。在低浓度时，ROS对包括精子成熟和活力在内的生理过程有积极影响。然而，ROS水平升高会通过氧化应激损害人类精子，主要原因是缺乏有效的DNA损伤修复机制和抗氧化防御不足。在本综述中，我们总结了特发性弱精子症中与ROS相关的生理和病理生理作用、内源性和外源性来源以及治疗策略。最终，维持ROS浓度和抗氧化剂之间的适当平衡对于确保男性生殖健康至关重要。
