微波辐射诱导Fischer大鼠脑部氧化应激、认知障碍和炎症。
Microwave radiation induced oxidative stress, cognitive impairment and inflammation in brain of Fischer rats.
作者信息
Megha Kanu, Deshmukh Pravin Suryakantrao, Banerjee Basu Dev, Tripathi Ashok Kumar, Abegaonkar Mahesh Pandurang
机构信息
Environmental Biochemistry and Molecular Biology Laboratory, Department of Biochemistry, University College of Medical Sciences & G.T.B. Hospital (University of Delhi), Dilshad Garden, Delhi 110 095, India.
出版信息
Indian J Exp Biol. 2012 Dec;50(12):889-96.
Public concerns over possible adverse effects of microwave radiation emitted by mobile phones on health are increasing. To evaluate the intensity of oxidative stress, cognitive impairment and inflammation in brain of Fischer rats exposed to microwave radiation, male Fischer-344 rats were exposed to 900 MHz microwave radiation (SAR = 5.953 x 10(-4) W/kg) and 1800 MHz microwave radiation (SAR = 5.835 x 10(-4) W/kg) for 30 days (2 h/day). Significant impairment in cognitive function and induction of oxidative stress in brain tissues of microwave exposed rats were observed in comparison with sham exposed groups. Further, significant increase in level of cytokines (IL-6 and TNF-alpha) was also observed following microwave exposure. Results of the present study indicated that increased oxidative stress due to microwave exposure may contribute to cognitive impairment and inflammation in brain.
公众对手机发出的微波辐射可能对健康产生的不利影响的担忧日益增加。为了评估暴露于微波辐射的Fischer大鼠大脑中的氧化应激强度、认知障碍和炎症，将雄性Fischer-344大鼠暴露于900 MHz微波辐射（比吸收率=5.953×10⁻⁴W/kg）和1800 MHz微波辐射（比吸收率=5.835×10⁻⁴W/kg）30天（每天2小时）。与假暴露组相比，在暴露于微波的大鼠脑组织中观察到认知功能显著受损和氧化应激诱导。此外，微波暴露后还观察到细胞因子（IL-6和TNF-α）水平显著升高。本研究结果表明，微波暴露引起的氧化应激增加可能导致大脑中的认知障碍和炎症。
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