Panchenko S V
Biull Eksp Biol Med. 1989 May;107(5):540-2.
During the experiment conducted upon 85 guinea-pigs it has been found that the injection of naloxone at the dose of 0.5 g/kg half an hour before the reproduction of anaphylactic shock (AS) by the use of horse serum increases the number of cases of the retarded development of pathological reaction and survival of the animals. Except for the quantitative differences mentioned any peculiarities characterizing the effect of naloxone were not found. As to the morphological differences of variants in the course of AS they are distinctly defined only at the analysis of film preparations of the intestinal mesentery. The typical AS becomes apparent by haemorrhages, by dilatation of all the vessels of blood circulation and by forming of erythrocytic aggregates in them. At the retarded development of AS a spasm of precapillaries is observed. After convalescence of the animals the aggregates of erythrocytes can be revealed only in venules. Studying the animals recovered after AS one can find that for a long time these animals had the erythrocytic aggregates in the clearances of venules, as well as the signs of new formation of the capillaries.
在对85只豚鼠进行的实验中发现，在使用马血清诱发过敏性休克（AS）前半小时注射剂量为0.5克/千克的纳洛酮，可增加病理反应发展延迟的病例数量以及动物的存活率。除了上述数量差异外，未发现纳洛酮作用的任何特殊特征。至于AS过程中不同变体的形态学差异，只有在分析肠系膜薄膜制剂时才能明确界定。典型的AS表现为出血、所有血液循环血管扩张以及其中形成红细胞聚集体。在AS发展延迟时，观察到毛细血管前括约肌痉挛。动物康复后，仅在小静脉中可发现红细胞聚集体。研究AS后恢复的动物发现，这些动物在很长一段时间内小静脉间隙中存在红细胞聚集体，以及毛细血管新生的迹象。
