Kumar Pradeep, Yadav Arun Kumar, Misra Shubham, Kumar Amit, Chakravarty Kamalesh, Prasad Kameshwar
a Department of Neurology, Neurosciences Centre, All India Institute of Medical Sciences , New Delhi , India.
Neurol Res. 2016 Sep;38(9):823-30. doi: 10.1080/01616412.2016.1202395. Epub 2016 Jun 30.
The role of anti-inflammatory Interleukin-10 (IL-10) cytokine gene polymorphism with the risk of ischemic stroke (IS) remains controversial. The aim of present meta-analysis was to investigate the association of IL-10 (-1082 A/G) gene polymorphism with the risk of IS. A literature search for candidate gene association studies published before 29 February 2016 was conducted in the PubMed, EMBASE, Google Scholar, and TRIP database. The following search terms were used: 'Interleukin-10' or 'IL-10' and 'Ischemic stroke' or 'IS' and 'Cerebral Infarction' or 'CI' and 'genetic polymorphism' or 'single nucleotide polymorphisms' or 'SNP'. Fixed or random effects models were used to estimate the pooled odds ratios (ORs) and 95% confidence intervals (CIs). Begg's funnel plot was used to assess the potential for publication bias. In our meta-analysis, five case-control studies involving 1209 IS cases and 1139 controls were included. Overall, there was no significant association between IL-10 (-1082 A/G) [rs1800896] and risk of IS under dominant [AA + AG vs. GG], recessive [AA vs. AG + GG], and allelic [G vs.A] models. However, based on Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification, we observed significant association of IL-10 (-1082 A/G) gene polymorphism with the risk of IS for Large Vessel Disease (LVD), Small Vessel Disease (SVD), and other (others due to determined and undetermined etiology) subtypes of IS. This is the first meta-analysis to conclude that IL-10-1082A/G gene polymorphism is associated with the risk of LVD, SVD, and other subtypes of IS. Further well-designed large sample size studies based on TOAST classification are needed to validate these findings.
抗炎细胞因子白细胞介素-10（IL-10）基因多态性与缺血性卒中（IS）风险之间的关系仍存在争议。本荟萃分析的目的是研究IL-10（-1082 A/G）基因多态性与IS风险之间的关联。于2016年2月29日前发表的候选基因关联研究在PubMed、EMBASE、谷歌学术和TRIP数据库中进行文献检索。使用了以下检索词：“白细胞介素-10”或“IL-10”以及“缺血性卒中”或“IS”以及“脑梗死”或“CI”以及“基因多态性”或“单核苷酸多态性”或“SNP”。采用固定或随机效应模型来估计合并比值比（OR）和95%置信区间（CI）。使用Begg漏斗图评估发表偏倚的可能性。在我们的荟萃分析中，纳入了五项病例对照研究，涉及1209例IS病例和1139例对照。总体而言，在显性模型[AA + AG vs. GG]、隐性模型[AA vs. AG + GG]和等位基因模型[G vs. A]下，IL-10（-1082 A/G）[rs1800896]与IS风险之间无显著关联。然而，基于急性卒中治疗中奥扎格雷钠（Org 10172）试验（TOAST）分类，我们观察到IL-10（-1082 A/G）基因多态性与大动脉疾病（LVD）、小血管疾病（SVD）以及IS的其他（病因已确定和未确定的其他类型）亚型的IS风险存在显著关联。这是第一项得出IL-10 - 1082A/G基因多态性与LVD、SVD及其他IS亚型风险相关的荟萃分析。需要基于TOAST分类进行进一步设计良好的大样本研究来验证这些发现。
