Abedinzadeh Mostafa, Neamatzadeh Hossein, Jafari Mohammadali, Forat-Yazdi Mohammad, Nasiri Rezvan, Farahnak Soudabeh, Foroughi Elnaz, Zare-Shehneh Masoud
. Department of Internal Medicine, Kashan University of Medical Sciences, Kashan, Isfahan, Iran.
. Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Rev Assoc Med Bras (1992). 2018 Aug;64(8):756-764. doi: 10.1590/1806-9282.64.08.756.
The association between the between IL-10 -1082A>G (rs1800896) polymorphism and breast cancer has been evaluated by several number case-control studies. However, these studies might be underpowered to reveal the true association.
We have performed a comprehensive meta-analysis to investigate the association IL-10 -1082A>G polymorphism and breast cancer.
A systematic literature search was conducted using PubMed, Google Scholar, and Web of Science up to September 20, 2017. Data was analysed with CMA software to identify the strength of the association by pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs).
A total of 17 case-control studies involving 3275 cases and 3416 controls obtained from database searches were examined. Overall, there was no significant association between IL-10 -1082A>G polymorphism and breast cancer risk under all genetic models. No significant publication bias was found for the five genetic models (G vs.
OR = 1.184, 95% CI = 0.895-1.180, p= 0.230; GG vs. AA: OR = 1.430, 95% CI = 0.927-2.204, p= 0.106; GA vs. AA: OR = 0.966, 95% CI = 0.765-1.221, p= 0.774; GG+GA vs. AA: OR = 0.957, 95% CI = 0.697-1.314, p= 0.786; and GG vs. GA+AA: OR = 1.221, 95% CI = 0.981-1.518, p= 0.073). Moreover, there was no significant association between the IL-10 -1082A>G polymorphism and breast cancer risk by ethnicity.
Our findings indicated that IL-10 -1082A>G (rs1800896) polymorphism might not be a risk factor for the development of breast cancer.
多项病例对照研究评估了白细胞介素10（IL-10）-1082A>G（rs1800896）基因多态性与乳腺癌之间的关联。然而，这些研究可能因检验效能不足而无法揭示真正的关联。
我们进行了一项全面的荟萃分析，以研究IL-10 -1082A>G基因多态性与乳腺癌之间的关联。
截至2017年9月20日，使用PubMed、谷歌学术和科学网进行了系统的文献检索。使用CMA软件分析数据，通过合并比值比（OR）及相应的95%置信区间（CI）来确定关联强度。
共检查了从数据库搜索中获得的17项病例对照研究，涉及3275例病例和3416例对照。总体而言，在所有遗传模型下，IL-10 -1082A>G基因多态性与乳腺癌风险之间均无显著关联。在五种遗传模型中未发现显著的发表偏倚（G vs. A：OR = 1.184，95% CI = 0.895 - 1.180，p = 0.230；GG vs. AA：OR = 1.430，95% CI = 0.927 - 2.204，p = 0.106；GA vs. AA：OR = 0.966，95% CI = 0.765 - 1.221，p = 0.774；GG + GA vs. AA：OR = 0.957，95% CI = 0.697 - 1.314，p = 0.786；GG vs. GA + AA：OR = 1.221，95% CI = 0.981 - 1.518，p = 0.073）。此外，按种族划分，IL-10 -1082A>G基因多态性与乳腺癌风险之间也无显著关联。
我们的研究结果表明，IL-10 -1082A>G（rs1800896）基因多态性可能不是乳腺癌发生的危险因素。
