Zuo Shuang, Zheng Tingting, Li Haishan
Medicine (Baltimore). 2020 Jan;99(5):e18858. doi: 10.1097/MD.0000000000018858.
The Interleukin-10 -1082A/G polymorphism has been indicated to be correlated with ischemic stroke susceptibility, but the results of studies are still debatable. Thus, a meta-analysis was carried out.Databases including PubMed, Embase, and CNKI were searched. Data were extracted and odds ratios (OR) with 95% confidence intervals (CI) were calculated.12 case-control studies with 2722 cases and 2405 controls were included in this meta-analysis. IL-10 -1082A/G polymorphism may decrease the risk of ischemic stroke (G vs A: OR = 0.72, 95% CI: 0.59-0.87; GG vs AA: OR = 0.59, 95% CI:0.48-0.74; AG vs AA: OR = 0.69, 95% CI: 0.51-0.93; GG+AG vs AA: OR = 0.65, 95% CI: 0.50-0.84; GG vs AG+AA: OR = 0.71, 95% CI: 0.55-0.93). Meanwhile, similar results were also observed in matched studies, hospital-based subgroup, Asians, and large sample-size studies.In conclusion, this meta-analysis suggested that the IL-10 -1082A/G polymorphism contributes to decreased ischemic stroke risk. Further large-scale and well-designed studies are still needed to confirm the results of our meta-analysis.
白细胞介素-10（IL-10）-1082A/G多态性已被表明与缺血性中风易感性相关，但研究结果仍存在争议。因此，进行了一项荟萃分析。检索了包括PubMed、Embase和中国知网在内的数据库。提取数据并计算比值比（OR）及95%置信区间（CI）。本荟萃分析纳入了12项病例对照研究，共2722例病例和2405例对照。IL-10 -1082A/G多态性可能会降低缺血性中风的风险（G与A比较：OR = 0.72，95% CI：0.59 - 0.87；GG与AA比较：OR = 0.59，95% CI：0.48 - 0.74；AG与AA比较：OR = 0.69，95% CI：0.51 - 0.93；GG + AG与AA比较：OR = 0.65，95% CI：0.50 - 0.84；GG与AG + AA比较：OR = 0.71，95% CI：0.55 - 0.93）。同时，在匹配研究、基于医院的亚组、亚洲人群和大样本量研究中也观察到了类似结果。总之，本荟萃分析表明IL-10 -1082A/G多态性有助于降低缺血性中风风险。仍需要进一步的大规模且设计良好的研究来证实我们荟萃分析的结果。
