氮杂吲哚的 N-杂环卡宾双活化催化合成。
Azaindole synthesis through dual activation catalysis with N-heterocyclic carbenes.
机构信息
Department of Chemistry, Department of Pharmacology, Center for Molecular Innovation and Drug Discovery, Chemistry of Life Processes Institute, Northwestern University, Silverman Hall, Evanston, Illinois 60208, USA.
出版信息
Chem Commun (Camb). 2016 Jul 28;52(59):9283-6. doi: 10.1039/c6cc04735a. Epub 2016 Jul 1.
Abstract
A convergent, transition-metal-free synthesis of 2-aryl-azaindoles has been developed. The interception of a reactive aza-ortho-azaquinone methide intermediate by an acyl anion equivalent generated through carbene catalysis provides high yields, a wide substrate scope, and the synthesis of previously inaccessible azaindoles.
摘要
一种收敛的、无需过渡金属的 2-芳基-氮杂吲哚合成方法已经开发出来。通过卡宾催化生成的酰基阴离子等价物捕获反应性的氮杂邻-氮杂醌甲叉中间体，可以得到高产率、广泛的底物范围，以及以前无法获得的氮杂吲哚的合成。
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