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本文引用的文献

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Intrathecal/intraventricular colistin in external ventricular device-related infections by multi-drug resistant Gram negative bacteria: case reports and review.鞘内/脑室内注射多粘菌素治疗耐多药革兰阴性菌所致的脑室外引流装置相关感染：病例报告及文献复习
Infection. 2014 Oct;42(5):801-9. doi: 10.1007/s15010-014-0618-0. Epub 2014 Apr 12.
2
Bundle of measures for external cerebral ventricular drainage-associated ventriculitis.外部脑室引流相关性脑室炎的综合防治措施。
Crit Care Med. 2014 Jan;42(1):66-73. doi: 10.1097/CCM.0b013e31829a70a5.
3
Renal and neurological side effects of colistin in critically ill patients.危重症患者中黏菌素的肾和神经毒性作用。
Ann Intensive Care. 2011 May 25;1(1):14. doi: 10.1186/2110-5820-1-14.
4
Post-neurosurgical multidrug-resistant Acinetobacter baumannii meningitis successfully treated with intrathecal colistin. A new case and a systematic review of the literature.神经外科术后多重耐药鲍曼不动杆菌脑膜炎经鞘内注射黏菌素治疗成功。1 例新病例及文献系统回顾。
Int J Infect Dis. 2010 Jul;14(7):e572-9. doi: 10.1016/j.ijid.2009.06.032. Epub 2009 Nov 4.
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Management of meningitis due to antibiotic-resistant Acinetobacter species.耐抗生素不动杆菌属所致脑膜炎的管理
Lancet Infect Dis. 2009 Apr;9(4):245-55. doi: 10.1016/S1473-3099(09)70055-6.
6
A review of clinical and microbiological outcomes following treatment of infections involving multidrug-resistant Acinetobacter baumannii with tigecycline.用替加环素治疗多重耐药鲍曼不动杆菌感染后的临床和微生物学结果综述。
J Antimicrob Chemother. 2009 Apr;63(4):775-80. doi: 10.1093/jac/dkn555. Epub 2009 Jan 21.
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Guidelines for the management of severe traumatic brain injury. VII. Intracranial pressure monitoring technology.重型颅脑损伤管理指南。VII. 颅内压监测技术。
J Neurotrauma. 2007;24 Suppl 1:S45-54. doi: 10.1089/neu.2007.9989.
8
Successful treatment of multidrug-resistant Acinetobacter baumannii central nervous system infections with colistin.用黏菌素成功治疗多重耐药鲍曼不动杆菌中枢神经系统感染
J Clin Microbiol. 2005 Sep;43(9):4916-7. doi: 10.1128/JCM.43.9.4916-4917.2005.
9
Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections.黏菌素：多黏菌素用于治疗多重耐药革兰氏阴性菌感染的复兴
Clin Infect Dis. 2005 May 1;40(9):1333-41. doi: 10.1086/429323. Epub 2005 Mar 22.
10
Practice guidelines for the management of bacterial meningitis.细菌性脑膜炎管理实践指南。
Clin Infect Dis. 2004 Nov 1;39(9):1267-84. doi: 10.1086/425368. Epub 2004 Oct 6.

多粘菌素和替加环素用于治疗由多重耐药鲍曼不动杆菌引起的与体外心室装置相关的脑室炎。

Colistin and tigecycline for management of external ventricular device-related ventriculitis due to multidrug-resistant Acinetobacter baumannii.

作者信息

Shrestha Gentle Sunder, Tamang Sushil, Paneru Hem Raj, Shrestha Pramesh Sunder, Keyal Niraj, Acharya Subhash Prasad, Marhatta Moda Nath, Shilpakar Sushil

机构信息

Department of Anaesthesiology, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

Department of Surgery, Neurosurgery Unit, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

出版信息

J Neurosci Rural Pract. 2016 Jul-Sep;7(3):450-2. doi: 10.4103/0976-3147.176194.

DOI:10.4103/0976-3147.176194
PMID:27365967
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4898118/
Abstract

Acinetobacter baumannii is an important cause of nosocomial ventriculitis associated with external ventricular device (EVD). It is frequently multidrug resistant (MDR), carries a poor outcome, and is difficult to treat. We report a case of MDR Acinetobacter ventriculitis treated with intravenous and intraventricular colistin together with intravenous tigecycline. The patient developed nephrotoxicity and poor neurological outcome despite microbiological cure. Careful implementation of bundle of measures to minimize EVD-associated ventriculitis is valuable.

摘要

鲍曼不动杆菌是与外部脑室引流装置（EVD）相关的医院内脑室炎的重要病因。它常常具有多重耐药性（MDR），预后不良，且难以治疗。我们报告一例多重耐药鲍曼不动杆菌脑室炎患者，采用静脉和脑室内注射黏菌素联合静脉注射替加环素进行治疗。尽管微生物学上已治愈，但该患者仍出现了肾毒性且神经功能预后不佳。谨慎实施一系列措施以尽量减少与EVD相关的脑室炎是很有价值的。