Siram Karthik, Marslin Gregory, Raghavan Chellan Vijaya, Balakumar Krishnamoorthy, Rahman Habibur, Franklin Gregory
Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore, India.
Centre for the Research and Technology of Agro-Environment and Biological Sciences, University of Minho, Braga, Portugal.
Int J Nanomedicine. 2016 Jun 15;11:2867-72. doi: 10.2147/IJN.S105852. eCollection 2016.
For targeted delivery of colloids to the lymphatic system, the colloids should efficiently reach and remain in the lymphatics for a considerable period of time. As per the current knowledge, diffusion and phagocytosis are the two mechanisms through which colloids reach the lymphatic system. Several parameters including particle size and charge have been shown to affect the direct uptake of colloids by the lymphatic system. Although many researchers attached ligands on the surface of colloids to promote phagocytosis-mediated lymphatic delivery, another school of thought suggests avoidance of phagocytosis by use of carriers like polyethylene glycol (PEG)ylated colloids to impart stealth attributes and evade phagocytosis. In this perspective, we weigh up the paradoxical theories and approaches available in the literature to draw conclusions on the conditions favorable for achieving efficient lymphatic targeting of colloids.
为了将胶体靶向递送至淋巴系统，胶体应有效到达并在淋巴管中停留相当长的一段时间。根据目前的知识，扩散和吞噬作用是胶体进入淋巴系统的两种机制。包括粒径和电荷在内的几个参数已被证明会影响淋巴系统对胶体的直接摄取。尽管许多研究人员在胶体表面连接配体以促进吞噬作用介导的淋巴递送，但另一种观点认为，通过使用聚乙二醇（PEG）化胶体等载体来赋予隐身特性并逃避吞噬作用，从而避免吞噬作用。从这个角度出发，我们权衡了文献中可用的矛盾理论和方法，以得出有利于实现胶体高效淋巴靶向的条件的结论。
