Kuehnl Alexander, Musiol Agnes, Raabe Carsten A, Rescher Ursula
Biol Chem. 2016 Oct 1;397(10):949-59. doi: 10.1515/hsz-2016-0183.
Emerging infectious diseases and drug-resistant infectious agents call for the development of innovative antimicrobial strategies. With pathogenicity now considered to arise from the complex and bi-directional interplay between a microbe and the host, host cell factor targeting has emerged as a promising approach that might overcome the limitations of classical antimicrobial drug development and could open up novel and efficient therapeutic strategies. Interaction with and modulation of host cell membranes is a recurrent theme in the host-microbe relationship. In this review, we provide an overview of what is currently known about the role of the Ca2+ dependent, membrane-binding annexin protein family in pathogen-host interactions, and discuss their emerging functions as host cell derived auxiliary proteins in microbe-host interactions and host cell targets.
新发传染病和耐药性感染因子促使人们开发创新的抗菌策略。鉴于现在认为致病性源于微生物与宿主之间复杂的双向相互作用，靶向宿主细胞因子已成为一种有前景的方法，它可能克服传统抗菌药物开发的局限性，并可能开辟新的高效治疗策略。与宿主细胞膜的相互作用和调节是宿主 - 微生物关系中的一个反复出现的主题。在本综述中，我们概述了目前已知的钙依赖性膜结合膜联蛋白蛋白家族在病原体 - 宿主相互作用中的作用，并讨论了它们作为宿主细胞衍生的辅助蛋白在微生物 - 宿主相互作用和宿主细胞靶点中的新功能。
