Demirok Gülizar, Topalak Yasemin, Başaran Mustafa M, Ataç Gökçe K, Öztürk Sertaç, Sengün Ahmet
a Ophthalmology Department , Ufuk University Faculty of Medicine , Ankara , Turkey.
b Otorhinolaryngology Department , Ufuk University Faculty of Medicine , Ankara , Turkey.
Semin Ophthalmol. 2017;32(5):620-624. doi: 10.3109/08820538.2016.1141223. Epub 2016 Jul 1.
The choroid receives about 65-85% of ocular blood flow, which comes from the ophthalmic artery (OA), the first branch of the internal carotid artery (ICA). In the foveal avascular zone, there is no retinal vascular supply; therefore, choroidal blood supply plays a significant role in this subfoveal region. The ocular pulse amplitude (OPA) provides useful information about intraocular blood flow and is an indirect indicator of choroidal perfusion. In this study, we aimed to assess the correlation between the OPA, subfoveal choroidal thickness (CT), and ICA Doppler ultrasound findings in healthy eyes.
In total, 48 eyes of 48 healthy volunteers were included in this study. All eyes underwent detailed ophthalmic evaluation, including slit-lamp biomicroscopy, fundus examination, axial length, OPA measurements, and optical coherence tomography (OCT) with enhanced depth imaging mode. Carotid Doppler ultrasound examination was performed by the radiologist. The correlation between the OPA, subfoveal CT, and ICA Doppler findings [peak systolic velocity (PSV) and end-diastolic velocity (EDV)] were evaluated, considering gender and age.
The mean OPA was 3.06 ± 1.34 mmHg. The mean subfoveal CT was 305.85 ± 33.98 µm. The mean PSV and EDV of ICA were 73.25 ± 23.63 cm/s and 26.93 ± 13.42 cm/s, respectively. A moderate positive correlation was found between OPA and subfoveal CT (p = 0.001; rho = 0.481). This relationship was present in both men and women. While a positive correlation was found between the OPA and subfoveal CT in subjects under the age of 50 years, there was no correlation in those over the age of 50 years.
A fair correlation was found between the OPA and subfoveal CT in healthy subjects under the age of 50.
脉络膜接受约65 - 85%的眼部血流，这些血流来自颈内动脉（ICA）的第一分支眼动脉（OA）。在黄斑无血管区，没有视网膜血管供应；因此，脉络膜血液供应在该黄斑下区域起着重要作用。眼脉搏振幅（OPA）提供了有关眼内血流的有用信息，并且是脉络膜灌注的间接指标。在本研究中，我们旨在评估健康眼睛中OPA、黄斑下脉络膜厚度（CT）和ICA多普勒超声检查结果之间的相关性。
本研究共纳入48名健康志愿者的48只眼睛。所有眼睛均接受了详细的眼科评估，包括裂隙灯生物显微镜检查、眼底检查、眼轴长度、OPA测量以及采用增强深度成像模式的光学相干断层扫描（OCT）。由放射科医生进行颈动脉多普勒超声检查。考虑性别和年龄，评估OPA、黄斑下CT与ICA多普勒检查结果[收缩期峰值速度（PSV）和舒张末期速度（EDV）]之间的相关性。
平均OPA为3.06±1.34 mmHg。平均黄斑下CT为305.85±33.98 µm。ICA的平均PSV和EDV分别为73.25±23.63 cm/s和26.93±13.42 cm/s。发现OPA与黄斑下CT之间存在中度正相关（p = 0.001；rho = 0.481）。这种关系在男性和女性中均存在。虽然在50岁以下的受试者中发现OPA与黄斑下CT之间存在正相关，但在50岁以上的受试者中未发现相关性。
在50岁以下的健康受试者中，发现OPA与黄斑下CT之间存在适度相关性。
