Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, P. R. China.
Org Lett. 2016 Jul 15;18(14):3362-5. doi: 10.1021/acs.orglett.6b01493. Epub 2016 Jul 1.
An iron-catalyzed diastereoselective synthesis of unnatural chiral (S)-α-amino acids with γ-quaternary carbon centers has been developed. The protocol uses inexpensive iron salt as the catalyst, readily available 2-phthaloyl acrylamide and alkenes as the starting materials, and phenylsilane as the reductant, and the reactions were performed well in mixed solvent of 1,2-dichloroethane and ethylene glycol at room temperature. The method shows some advantages including simple and wide substrates, mild conditions, high diastereoselectivity, and easy workup procedures.
一种铁催化的非天然手性 (S)-α-氨基酸的γ-季碳中心的非对映选择性合成方法已经被开发出来。该方案使用廉价的铁盐作为催化剂，易得的 2-邻苯二甲酰亚胺基丙烯酰胺和烯烃作为起始原料，以及苯基硅烷作为还原剂，反应在室温下在 1,2-二氯乙烷和乙二醇的混合溶剂中进行得很好。该方法具有一些优点，包括简单和广泛的底物、温和的条件、高非对映选择性和易于处理的步骤。
