上帝奇迹的证据：挖掘一个RAG转座子。
Evidence of G.O.D.'s Miracle: Unearthing a RAG Transposon.
作者信息
Flajnik Martin F
机构信息
Department of Microbiology and Immunology, University of Maryland Baltimore, 685 West Baltimore St., Suite 380, Baltimore, MD 21201, USA.
出版信息
Cell. 2016 Jun 30;166(1):11-2. doi: 10.1016/j.cell.2016.06.021.
Abstract
Diversity of antibodies and T cell receptors is generated by gene rearrangement dependent on RAG1 and RAG2, enzymes predicted to have been derived from a transposable element (TE) that invaded an immunoglobulin superfamily gene early in the evolution of jawed vertebrates. Now, Huang et al. report the discovery of ProtoRAG in the lower chordate Amphioxus, the long-anticipated TE related to the RAG transposon.
摘要
抗体和T细胞受体的多样性是通过依赖RAG1和RAG2的基因重排产生的，这两种酶被认为起源于一种转座元件（TE），该转座元件在有颌脊椎动物进化早期侵入了一个免疫球蛋白超家族基因。现在，黄等人报告了在低等脊索动物文昌鱼中发现了ProtoRAG，这是长期以来人们一直期待的与RAG转座子相关的转座元件。
相似文献
1
Evidence of G.O.D.'s Miracle: Unearthing a RAG Transposon.上帝奇迹的证据：挖掘一个RAG转座子。
Cell. 2016 Jun 30;166(1):11-2. doi: 10.1016/j.cell.2016.06.021.
2
New insights into the evolutionary origins of the recombination-activating gene proteins and V(D)J recombination.重组激活基因蛋白和V(D)J重组进化起源的新见解。
FEBS J. 2017 Jun;284(11):1590-1605. doi: 10.1111/febs.13990. Epub 2017 Jan 6.
3
The RAG transposon is active through the deuterostome evolution and domesticated in jawed vertebrates.RAG转座子在整个后口动物进化过程中都具有活性，并在有颌脊椎动物中被驯化。
Immunogenetics. 2017 Jun;69(6):391-400. doi: 10.1007/s00251-017-0979-5. Epub 2017 Apr 28.
4
Antigen receptor genes and the evolution of a recombinase.抗原受体基因与重组酶的进化
Semin Immunol. 2004 Aug;16(4):245-56. doi: 10.1016/j.smim.2004.08.004.
5
Transposition mediated by RAG1 and RAG2 and the evolution of the adaptive immune system.由RAG1和RAG2介导的转座与适应性免疫系统的进化
Immunol Res. 1999;19(2-3):169-82. doi: 10.1007/BF02786485.
6
Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination.活性RAG转座子的发现揭示了V(D)J重组的起源。
Cell. 2016 Jun 30;166(1):102-14. doi: 10.1016/j.cell.2016.05.032. Epub 2016 Jun 9.
7
Evolution of the RAG1-RAG2 locus: both proteins came from the same transposon.RAG1-RAG2基因座的进化：两种蛋白质均来自同一转座子。
Biol Direct. 2015 Apr 28;10:20. doi: 10.1186/s13062-015-0055-8.
8
Collaboration of RAG2 with RAG1-like proteins during the evolution of V(D)J recombination.V(D)J重组进化过程中RAG2与RAG1样蛋白的协作。
Genes Dev. 2016 Apr 15;30(8):909-17. doi: 10.1101/gad.278432.116. Epub 2016 Apr 7.
9
Transposon molecular domestication and the evolution of the RAG recombinase.转座子分子驯化与 RAG 重组酶的进化。
Nature. 2019 May;569(7754):79-84. doi: 10.1038/s41586-019-1093-7. Epub 2019 Apr 10.
10
Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system.由RAG1和RAG2介导的转座及其对免疫系统进化的影响。
Nature. 1998 Aug 20;394(6695):744-51. doi: 10.1038/29457.
引用本文的文献
1
Origin of immunoglobulins and T cell receptors: A candidate gene for invasion by the RAG transposon.免疫球蛋白和T细胞受体的起源：RAG转座子入侵的一个候选基因。
Sci Adv. 2025 Jul 4;11(27):eadw1273. doi: 10.1126/sciadv.adw1273.
2
The Janus (dual) model of immunoglobulin isotype evolution: Conservation and plasticity are the defining paradigms.免疫球蛋白同种型进化的两面（双重）模型：保守性和可塑性是决定性范式。
Immunol Rev. 2024 Nov;328(1):49-64. doi: 10.1111/imr.13389. Epub 2024 Sep 3.
3
An Ancient MHC-Linked Gene Encodes a Nonrearranging Shark Antibody, UrIg, Convergent with IgG.一个古老的 MHC 连锁基因编码了一个不重排的鲨鱼抗体，UrIg，与 IgG 趋同。
J Immunol. 2023 Sep 15;211(6):1042-1051. doi: 10.4049/jimmunol.2300361.
4
Analysis of shark NCR3 family genes reveals primordial features of vertebrate NKp30.分析鲨鱼 NCR3 家族基因揭示脊椎动物 NKp30 的原始特征。
Immunogenetics. 2021 Aug;73(4):333-348. doi: 10.1007/s00251-021-01209-6. Epub 2021 Mar 19.
5
LanceletDB: an integrated genome database for lancelet, comparing domain types and combination in orthologues among lancelet and other species.文昌鱼数据库：文昌鱼综合基因组数据库，比较文昌鱼与其他物种同源基因中外显子结构域类型和组合。
Database (Oxford). 2019 Jan 1;2019. doi: 10.1093/database/baz056.
6
Rearranged T Cell Receptor Sequences in the Germline Genome of Channel Catfish Are Preferentially Expressed in Response to Infection.重组 T 细胞受体序列在鲶鱼种系基因组中对感染的优先表达。
Front Immunol. 2018 Sep 27;9:2117. doi: 10.3389/fimmu.2018.02117. eCollection 2018.
7
A cold-blooded view of adaptive immunity.冷血的适应性免疫观。
Nat Rev Immunol. 2018 Jul;18(7):438-453. doi: 10.1038/s41577-018-0003-9.
本文引用的文献
1
Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination.活性RAG转座子的发现揭示了V(D)J重组的起源。
Cell. 2016 Jun 30;166(1):102-14. doi: 10.1016/j.cell.2016.05.032. Epub 2016 Jun 9.
2
Collaboration of RAG2 with RAG1-like proteins during the evolution of V(D)J recombination.V(D)J重组进化过程中RAG2与RAG1样蛋白的协作。
Genes Dev. 2016 Apr 15;30(8):909-17. doi: 10.1101/gad.278432.116. Epub 2016 Apr 7.
3
An amphioxus RAG1-like DNA fragment encodes a functional central domain of vertebrate core RAG1.文昌鱼 RAG1 样 DNA 片段编码脊椎动物核心 RAG1 的功能中心域。
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):397-402. doi: 10.1073/pnas.1318843111. Epub 2013 Dec 24.
4
The invention of lymphocytes.淋巴细胞的发现。
Curr Opin Immunol. 2011 Apr;23(2):156-62. doi: 10.1016/j.coi.2010.12.007. Epub 2011 Jan 10.
5
A brief history of the status of transposable elements: from junk DNA to major players in evolution.转座元件的简史：从“垃圾 DNA”到进化的主要参与者。
Genetics. 2010 Dec;186(4):1085-93. doi: 10.1534/genetics.110.124180.
6
The origins of the Rag genes--from transposition to V(D)J recombination.Rag 基因的起源——从转座到 V(D)J 重组。
Semin Immunol. 2010 Feb;22(1):10-6. doi: 10.1016/j.smim.2009.11.004. Epub 2009 Dec 9.
7
RAG1 core and V(D)J recombination signal sequences were derived from Transib transposons.RAG1核心序列和V(D)J重组信号序列源自转座子Transib。
PLoS Biol. 2005 Jun;3(6):e181. doi: 10.1371/journal.pbio.0030181. Epub 2005 May 24.
8
New insights into V(D)J recombination and its role in the evolution of the immune system.V(D)J重组及其在免疫系统进化中的作用的新见解。
Immunity. 1995 Nov;3(5):531-9. doi: 10.1016/1074-7613(95)90124-8.
9
The V(D)J recombination activating gene, RAG-1.V(D)J重组激活基因，RAG-1。
Cell. 1989 Dec 22;59(6):1035-48. doi: 10.1016/0092-8674(89)90760-5.
10
Sequences at the somatic recombination sites of immunoglobulin light-chain genes.免疫球蛋白轻链基因体细胞重组位点的序列。
Nature. 1979 Jul 26;280(5720):288-94. doi: 10.1038/280288a0.
Zotero 插件