Liehn J C, Hannequin P, Nasca S, Lebrun D, Fernandez-Valoni A, Valeyre J
Department of Nuclear Medicine, Institut Jean Godinot, Reims, France.
Clin Nucl Med. 1989 Mar;14(3):187-91. doi: 10.1097/00003072-198903000-00010.
A major drawback of In-111-labeled monoclonal antibodies (MoAb) is the presence of intense liver, renal, and bone marrow nonspecific activity. This makes the display of the images hardly optimal and their visual interpretation difficult. In this study, the "intrinsic color scale" (which consists of selecting the limits of the color scale as the highest and the lowest pixel value of the image) was compared to a new, simple algorithm for the determination of the limits of the color scale. This algorithm was based on the count density in the iliac crest areas. OC-125 or anti-CEA In-111 MoAb F(ab')2 fragments were used in 32 patients with suspected recurrence of ovarian (19 patients) or colorectal cancer (13 patients). Final diagnosis was assessed by surgery (21 patients), biopsy (five patients), or followup (six patients). A 10-minute abdomino-pelvic anterior view was recorded two days after injection. These views are displayed using the two methods and interpreted by two observers. Using their responses in each quadrant of the pelvis, the authors calculated two ROC curves. The comparison of the ROC curves showed better performances for the new method. For example, for the same specificity (73%), the sensitivity of the new method was significantly better (78% versus 68%). This result confirmed the importance of a good methodology for displaying immunoscintigraphic images.
铟 - 111标记的单克隆抗体（MoAb）的一个主要缺点是肝脏、肾脏和骨髓存在强烈的非特异性活性。这使得图像显示难以达到最佳状态，并且视觉解读也很困难。在本研究中，将“固有色标”（即选择色标的范围作为图像的最高和最低像素值）与一种用于确定色标范围的新的简单算法进行了比较。该算法基于髂嵴区域的计数密度。32例疑似卵巢癌复发（19例）或结直肠癌复发（13例）的患者使用了OC - 125或抗癌胚抗原铟 - 111单克隆抗体F(ab')2片段。最终诊断通过手术（21例患者）、活检（5例患者）或随访（6例患者）进行评估。注射后两天记录了10分钟的腹部 - 盆腔前视图。这些视图使用两种方法进行显示，并由两名观察者进行解读。作者根据他们在骨盆每个象限的反应计算了两条ROC曲线。ROC曲线的比较表明新方法具有更好的性能。例如，对于相同的特异性（73%），新方法的灵敏度明显更高（78%对68%）。这一结果证实了良好的图像显示方法的重要性。
