Kaomongkolgit Ruchadaporn, Jamdee Kusuma
Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University, Phitsanulok, 65000, Thailand.
Faculty of Dentistry, Dental Science Research Center, Naresuan University, Phitsanulok, 65000, Thailand.
Odontology. 2017 Apr;105(2):248-253. doi: 10.1007/s10266-016-0256-3. Epub 2016 Jul 1.
The objective of this study was to determine the inhibitory effect of alpha-mangostin on Candida biofilms. Candida species including Candida albicans, Candida krusei, Candida tropicalis, and Candida glabrata were tested. Candida biofilms were formed in flat-bottomed 96-well microtiter plates. The metabolic activity of cells within biofilms was quantified using the XTT assay. The results demonstrated that alpha-mangostin showed a significant anti-biofilm effect on both developing biofilms and preformed biofilms of Candida species. It may be concluded that alpha-mangostin could be an anti-biofilm agent against Candida species. Further in vivo investigations are needed to uncover the therapeutic values of this medicinal plant.
本研究的目的是确定α-山竹黄酮对念珠菌生物膜的抑制作用。测试了包括白色念珠菌、克柔念珠菌、热带念珠菌和光滑念珠菌在内的念珠菌属。在平底96孔微量滴定板中形成念珠菌生物膜。使用XTT测定法定量生物膜内细胞的代谢活性。结果表明，α-山竹黄酮对念珠菌属正在形成的生物膜和预先形成的生物膜均显示出显著的抗生物膜作用。可以得出结论，α-山竹黄酮可能是一种抗念珠菌属生物膜的药物。需要进一步的体内研究来揭示这种药用植物的治疗价值。
