Mostaan Saied, Yazdanpanah Bahador, Moukhah Rasool, Hozouri Hamid Reza, Rostami Manouchehr, Khorashadizadeh Mohsen, Zerehsaz Javad, Mahabadi Ramin Pirhajati, Saadi Arya, Khanahmad Hossein, Pooya Mohammad
Department of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran.
Department of BCG, Production and Research Complex, Pasteur Institute of Iran, Tehran, Iran.
Adv Biomed Res. 2016 Jun 8;5:99. doi: 10.4103/2277-9175.183659. eCollection 2016.
Although in the last two decades the World Health Organization (WHO) has introduced tuberculosis as "a threat to global", the vaccination with the Mycobacterium bovis Bacillus Calmette-Guerin (BCG) is the only way for the prevention of this fatal infectious disease. Despite of the efficacy of BCG vaccine especially against infants' meningitis, it has still some limitations due to a variety of adverse effects. Many studies have evaluated the side effects of different strains of BCG vaccines in different countries. In Iran, some studies have been done so far to evaluate the adverse effects of 1173 P2 strain which is used for BCG vaccination. Each of these studies have used different standardization and sampling methods. This review will survey all studies that have been published about adverse effects of 1173 P2 strain of BCG vaccine in Iran using data mining methods.
尽管在过去二十年里世界卫生组织（WHO）已将结核病列为“对全球的威胁”，但接种卡介苗（BCG）是预防这种致命传染病的唯一方法。尽管卡介苗疫苗，尤其是对预防婴儿脑膜炎很有效，但由于存在各种不良反应，它仍有一些局限性。许多研究评估了不同国家不同菌株卡介苗疫苗的副作用。在伊朗，迄今为止已经开展了一些研究来评估用于卡介苗接种的1173 P2菌株的不良反应。这些研究中的每一项都采用了不同的标准化和抽样方法。本综述将使用数据挖掘方法调查所有已发表的关于伊朗1173 P2菌株卡介苗疫苗不良反应的研究。
