Pediatric Infectious Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Braz J Infect Dis. 2011 Jan-Feb;15(1):83-6. doi: 10.1016/s1413-8670(11)70146-5.
Bacillus Calmette Guerin (BCG) vaccine, which is administered to all newborns in some regions, could lead to serious complication ranging from local disease (known as BCGitis) to disseminated disease (BCGosis) in a group of patients with primary immunodeficiency diseases. We are reporting here a 3.5 year-old girl with a history of prolonged BCGitis, which developed to disseminated disease without any other special features. Immunological studies with nitro-blue tetrazolium test confirmed the diagnosis of chronic granulomatous disease in this patient. Chronic granulomatous disease should be considered in the list of differential diagnosis in all children with BCGosis, even in the absence of any other manifestations related to immunodeficiency.
卡介苗（BCG）疫苗被用于一些地区的所有新生儿，可能会导致一组原发性免疫缺陷病患者出现严重并发症，从局部疾病（称为卡介苗炎）到播散性疾病（卡介苗病）。我们在此报告一例 3.5 岁女孩，有卡介苗炎病史，且病情发展为播散性疾病，无其他特殊特征。硝基四唑氮蓝试验的免疫研究证实了该患者患有慢性肉芽肿病。在所有患有卡介苗炎的儿童中，即使没有任何与免疫缺陷相关的其他表现，也应将慢性肉芽肿病列入鉴别诊断清单中。
