Lee Seung Ho, Choy Young Bin
Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, Korea.
Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea.
Int Neurourol J. 2016 Jun;20(2):101-6. doi: 10.5213/inj.1632664.332. Epub 2016 Jun 24.
In clinical settings, intravesical instillation of a drug bolus is often performed for the treatment of bladder diseases. However, it requires repeated instillations to extend drug efficacy, which may result in poor patient compliance. To alleviate this challenge, implantable devices have been developed for the purpose of sustained, intravesical drug delivery. In this review, we briefly summarize the current trend in the development of intravesical drug-delivery devices. We also introduce the most recently developed devices with strong potential for intravesical drug-delivery applications.
在临床环境中，通常通过膀胱内注入药物推注来治疗膀胱疾病。然而，这需要反复注入以延长药物疗效，这可能导致患者依从性差。为了应对这一挑战，已开发出可植入装置用于持续膀胱内给药。在本综述中，我们简要总结了膀胱内给药装置的当前发展趋势。我们还介绍了最近开发的、在膀胱内给药应用方面具有强大潜力的装置。
