Simonetta Federico, Pradier Amandine, Roosnek Eddy
Department of Medical Specialties, Division of Hematology, Geneva University Hospitals, University of Geneva , Geneva , Switzerland.
Front Immunol. 2016 Jun 20;7:241. doi: 10.3389/fimmu.2016.00241. eCollection 2016.
Recent reports give insights into the role of the T-box transcription factors, T-bet and Eomesodermin (Eomes), in NK cell biology. In this mini-review, we recapitulate the initial reports that delineate T-bet and Eomes as master regulators of NK cell development, maturation, and function. We discuss how T-bet and Eomes expression is regulated during NK cell development and peripheral maturation. Furthermore, we summarize the current literature on the role of T-bet and Eomes in the transcriptional regulation of NK cell function and review possible effects of T-box transcription factor anomalies during aging, infection, cancer, and after hematopoietic stem cell transplantation. We discuss how the current data argue in favor of a model of T-bet and Eomes synergy in transcriptional regulation of NK cell function and identify T-box transcription factors as potential targets for therapeutic interventions.
近期的报告揭示了T-box转录因子T-bet和胚外中胚层决定蛋白（Eomes）在自然杀伤（NK）细胞生物学中的作用。在这篇小型综述中，我们总结了最初的报告，这些报告将T-bet和Eomes描述为NK细胞发育、成熟和功能的主要调节因子。我们讨论了在NK细胞发育和外周成熟过程中T-bet和Eomes表达是如何被调控的。此外，我们总结了关于T-bet和Eomes在NK细胞功能转录调控中作用的当前文献，并回顾了衰老、感染、癌症以及造血干细胞移植后T-box转录因子异常可能产生的影响。我们讨论了当前数据如何支持T-bet和Eomes在NK细胞功能转录调控中协同作用的模型，并将T-box转录因子确定为治疗干预的潜在靶点。
