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通过无创反射式共聚焦显微镜对不同剃须刀对皮肤的影响进行量化。

The influence of different shavers on the skin quantified by non-invasive reflectance confocal microscopy.

作者信息

Rodijk F M W, Zanelli G, Geerligs M, van Erp P E J, Peppelman M

机构信息

Philips Consumer Lifestyle B.V., Drachten, The Netherlands.

Department of Dermatology, Radboud University Medical Centre, Nijmegen, The Netherlands.

出版信息

Skin Res Technol. 2016 Aug;22(3):311-7. doi: 10.1111/srt.12263. Epub 2015 Nov 2.

Abstract

BACKGROUND

The impact of personal care devices on skin is mainly assessed using subjective tools. However, new objective, accurate non-invasive in vivo imaging techniques have been developed. The aim of this study was to evaluate the ability of reflectance confocal microscopy (RCM) in quantifying morphological impact of shavers on skin. Furthermore, tape stripping (TS) as method to study morphological impact of shavers was evaluated.

METHODS

In 12 healthy male subjects, for two consecutive days, a split-face test was performed in the neck; on one side a shaver was applied, while the other side was exposed to TS. The stratum corneum (SC) thickness was quantified using RCM and sensory observations were evaluated using questionnaires.

RESULTS

Shavers with a different impact on skin, can be discriminated by RCM; shaver B removed more SC after application than the skin friendlier shaver A. Furthermore, the changes in SC thickness induced by TS corresponded well to that of the shavers.

CONCLUSION

RCM is able to quantify the impact of different shavers on skin. Besides, TS appeared to be a suitable model mimicking the mechanical impact of shavers on skin. RCM in combination with the TS model appeared to be a suitable minimally invasive model to obtain morphological and cell biological data on skin-material interactions caused by different personal care devices.

摘要

背景

个人护理设备对皮肤的影响主要通过主观工具进行评估。然而,新的客观、准确的非侵入性体内成像技术已经得到开发。本研究的目的是评估反射式共聚焦显微镜(RCM)在量化剃须刀对皮肤形态学影响方面的能力。此外,还评估了胶带剥离(TS)作为研究剃须刀形态学影响的方法。

方法

在12名健康男性受试者的颈部连续两天进行半脸试验;一侧使用剃须刀,另一侧进行胶带剥离。使用RCM量化角质层(SC)厚度,并通过问卷调查评估感官观察结果。

结果

RCM能够区分对皮肤有不同影响的剃须刀;使用后,剃须刀B比更温和的剃须刀A去除了更多的SC。此外,TS引起的SC厚度变化与剃须刀的情况非常吻合。

结论

RCM能够量化不同剃须刀对皮肤的影响。此外,TS似乎是一种模拟剃须刀对皮肤机械影响的合适模型。RCM与TS模型相结合似乎是一种合适的微创模型,可用于获取不同个人护理设备引起的皮肤-材料相互作用的形态学和细胞生物学数据。

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