Arvelo Francisco, Sojo Felipe, Cotte Carlos
Invest Clin. 2016 Mar;57(1):77-92.
Since the mid-twentieth century, many species, very different from each other and located in all areas and comers of the planet, began presenting various alterations, many of which suggested to be related to endocrine disorders. Research has shown that such alterations were caused by exposure to various chemical contaminants that could affect the health and cause serious illnesses. Among them stands a diverse and large group of compounds, with very different chemical structures, capable of altering the hormonal balance, act at very low doses and with different mechanisms of action, that are called "endocrine disrupting chemicals". When released into the environment or as part of objects, food or medicines, constitute a major risk to animals and humans, which produces not only endocrine dysfunctions but also different cancers, which include the most common types. Despite the importance and significance of the impact of these compounds, they are not sufficiently known or understood, so the aim of this review is to show their origin and impact in the field of human health, highlighting their role as inducers of cancer, which has led to multiple clinical and biological investigations.
自20世纪中叶以来，许多彼此差异很大且分布在地球各个区域和角落的物种开始出现各种变化，其中许多变化被认为与内分泌紊乱有关。研究表明，这些变化是由接触各种化学污染物引起的，这些污染物会影响健康并导致严重疾病。其中有一类多样且庞大的化合物，它们具有非常不同的化学结构，能够改变激素平衡，在极低剂量下发挥作用且作用机制不同，这类化合物被称为“内分泌干扰化学物质”。当它们释放到环境中或作为物体、食物或药品的一部分时，会对动物和人类构成重大风险，不仅会导致内分泌功能障碍，还会引发包括最常见类型在内的各种癌症。尽管这些化合物的影响至关重要且意义重大，但人们对它们的了解还不够充分，因此本综述的目的是展示它们在人类健康领域的起源和影响，突出它们作为癌症诱导剂的作用，这引发了多项临床和生物学研究。
