Mercado Borja, Vila Borja, Roca-Pérez Luis, Duran-Giner Neus, Boluda-Hernández Rafael, Andreu-Sánchez Oscar
Department of Biomedical Sciences, Faculty of Health Sciences, European University of Valencia, Paseo de La Alameda, 7, 46010 Valencia, Spain.
Departamento de Biología Vegetal, Facultad de Farmacia, Universitat de València, 46100 Burjassot, Spain.
Toxics. 2025 Jul 7;13(7):572. doi: 10.3390/toxics13070572.
Industry currently generates numerous substances, such as food additives, whose environmental impacts, particularly in marine environments, remain inadequately assessed. This study employed for the first time as a model organism to evaluate the toxicity of such compounds. The main goal was to evaluate the toxicity of two food additives, 2-methyl-1-phenylpropan-2-ol (S1) and 1-phenylethan-1-ol (S2), on ephyrae, comparing the results with other organisms representing different trophic levels, specifically the alga and the crustacean . Acute toxicity tests were conducted on each organism. In , S1 exhibited high toxicity (LC ≈ 10 mg/L), while S2 had lower toxicity (LC ≈ 80 mg/L). The pulsation frequency data for revealed that S1 initially increased the pulsation rates at lower concentrations (maximum at 10 mg/L), followed by a significant decrease at higher concentrations. Conversely, S2 showed a steady decrease in pulsation rates up to 10 mg/L, with a slight increase at concentrations of 15, 20, and 25 mg/L. The results demonstrate varying sensitivities to the toxic effects of the two compounds across different trophic levels, with ephyrae being the most sensitive. This suggests the potential efficacy of jellyfish as novel ecotoxicological models due to their heightened sensitivity, enabling the detection of lower contaminant concentrations in test samples. Further research is required to enhance the efficiency of ecotoxicological assays using this model.
工业目前产生了大量物质，如食品添加剂，其对环境的影响，尤其是在海洋环境中的影响，仍未得到充分评估。本研究首次使用[具体生物名称]作为模式生物来评估此类化合物的毒性。主要目标是评估两种食品添加剂，2-甲基-1-苯基丙-2-醇（S1）和1-苯基乙-1-醇（S2）对[具体生物名称]碟状幼体的毒性，并将结果与代表不同营养级别的其他生物，特别是藻类[藻类具体名称]和甲壳类动物[甲壳类动物具体名称]进行比较。对每种生物都进行了急性毒性试验。在[具体生物名称]中，S1表现出高毒性（LC≈10毫克/升），而S2毒性较低（LC≈80毫克/升）。[具体生物名称]的脉动频率数据显示，S1在较低浓度下最初会增加脉动率（在10毫克/升时达到最大值），随后在较高浓度下显著下降。相反，S2在浓度达到10毫克/升之前脉动率稳步下降，在15、20和25毫克/升时略有增加。结果表明，不同营养级别的生物对这两种化合物的毒性影响具有不同的敏感性，其中[具体生物名称]碟状幼体最为敏感。这表明水母作为新型生态毒理学模型具有潜在的有效性，因为它们具有更高的敏感性，能够检测测试样品中更低的污染物浓度。需要进一步研究以提高使用该模型的生态毒理学检测效率。
