Kim Boyun, Song Yong Sang
a Cancer Research Institute, College of Medicine , Seoul National University , Seoul , Korea.
b Nano System Institute, Seoul National University , Seoul , Korea.
Free Radic Res. 2016 Oct;50(10):1065-1070. doi: 10.1080/10715762.2016.1210141. Epub 2016 Aug 25.
Mitochondria as crucial organelles regulate cellular energy generation, calcium and redox homeostasis, and apoptosis. To perform the cellular functions effectively, mitochondria continuously change their structure and morphology through protein machineries controlling fission and fusion process (mitochondrial dynamics). Traditionally, many researches had focused on the interaction of mitochondrial dynamics and apoptosis. However, recent studies are reporting the alteration of mitochondrial dynamics in human diseases including many types of cancers. Considering that cancers maintain a high level of reactive oxygen species (ROS), mitochondrial dynamics can be influenced by oxidative stress. In this review, we will discuss the alteration of mitochondrial dynamics by ROS and its effect on metastasis and chemoresistance in cancers.
线粒体作为关键细胞器，调控细胞能量生成、钙和氧化还原稳态以及细胞凋亡。为有效执行细胞功能，线粒体通过控制裂变和融合过程（线粒体动力学）的蛋白质机制不断改变其结构和形态。传统上，许多研究聚焦于线粒体动力学与细胞凋亡的相互作用。然而，最近的研究报道了包括多种癌症在内的人类疾病中线粒体动力学的改变。鉴于癌症维持高水平的活性氧（ROS），线粒体动力学可能受氧化应激影响。在本综述中，我们将讨论ROS引起的线粒体动力学改变及其对癌症转移和化疗耐药性的影响。
