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绒毛膜癌肺肿瘤栓塞的治疗:体外膜肺氧合作为化疗的桥梁

Treatment of Pulmonary Tumor Embolism from Choriocarcinoma: Extracorporeal Membrane Oxygenation as a Bridge through Chemotherapy.

作者信息

Chung Jae Heun, Yeo Hye Ju, Cho Hyun Myung, Jang Jin Ook, Ye Byung Min, Yoon Gun, Shin Dong Hoon, Kim Dohyung, Cho Woo Hyun

机构信息

Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.

Department of Obstetrics and Gynecology, Pusan National University Yangsan Hospital, Yangsan, Korea.

出版信息

Cancer Res Treat. 2017 Jan;49(1):279-282. doi: 10.4143/crt.2016.125. Epub 2016 Jun 24.

Abstract

A 22-year-old woman with a 1-month history of shortness of breath that was treated as a case of tuberculosis and pulmonary embolism was referred to the authors' hospital. Because of the hemodynamic instability in this patient, venoarterial extracorporeal membrane oxygenation (ECMO) was administered in the intensive care unit. She underwent a pulmonary embolectomy for the treatment of progressive circulatory collapse secondary to a pulmonary embolism. The histopathologic result was consistent with a metastatic choriocarcinoma. Despite the surgical management, persistent refractory cardiogenic shock occurred. Subsequently, the patient was treated with chemotherapy in the presence of ECMO and responded well to chemotherapy. She was discharged after 3 months. This case suggests that metastatic choriocarcinoma should be considered as a differential diagnosis in women of childbearing age presenting with a pulmonary embolism, and ECMO may be beneficial in patients with pulmonary embolism for bridging to surgical embolectomy and chemotherapy.

摘要

一名22岁女性,有1个月的气短病史,曾被当作肺结核和肺栓塞病例进行治疗,后被转诊至作者所在医院。由于该患者存在血流动力学不稳定,在重症监护病房进行了静脉-动脉体外膜肺氧合(ECMO)治疗。她接受了肺栓子切除术,以治疗继发于肺栓塞的进行性循环衰竭。组织病理学结果与转移性绒毛膜癌一致。尽管进行了手术治疗,但仍出现了持续性难治性心源性休克。随后,患者在使用ECMO的情况下接受化疗,对化疗反应良好。3个月后出院。该病例提示,对于出现肺栓塞的育龄女性,应将转移性绒毛膜癌视为鉴别诊断之一,并且ECMO对于肺栓塞患者在过渡到手术栓子切除术和化疗方面可能有益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f24/5266394/0bc874c5f4e6/crt-2016-125f1.jpg

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