Fujimoto J, Fujita H, Hosoda S, Okada H, Tamaya T
Nihon Gan Chiryo Gakkai Shi. 1989 Jan 20;24(1):21-31.
The relationship among the prognosis of a patient with cancer of the cervix and endocrine background [production of estrogen receptor (ER), progestogen receptor (PR), and androgen receptor (AR)], clinical stage, histological type, lymph node metastasis, age, and treatment was studied. ERs were detected in almost all cases, regardless of the histological type of cancer. The detection rate and level of PR were in the decreasing order of large-cell non-keratinizing (LNK) carcinoma, keratinizing (K) carcinoma, and small-cell non-keratinizing (SNK) carcinoma of the cervix. Thus, the presence and level of PR in squamous cell carcinoma of the cervix were considered to be an indicator of the degree of differentiation. PR was not detected in cases of adenocarcinoma of the cervix. This may explain the poor responsiveness to progestogen treatment in adenocarcinoma of the cervix. There was no relationship between the patient's prognosis and the presence of PR or AR, but the prognosis of patients with lesions rich in ER (greater than or equal to 5 fmol/micrograms DNA) tended to be better than that of patients with lesions poor in ER (less than 5 fmol/micrograms DNA). The prognosis of patients before menopause tended to be better than that postmenopause. These findings indicate a relationship between cancer of the cervix and endocrine background.
研究了子宫颈癌患者的预后与内分泌背景[雌激素受体（ER）、孕激素受体（PR）和雄激素受体（AR）的产生]、临床分期、组织学类型、淋巴结转移、年龄及治疗之间的关系。几乎在所有病例中均检测到ER，无论癌症的组织学类型如何。PR的检出率和水平按子宫颈大细胞非角化（LNK）癌、角化（K）癌和小细胞非角化（SNK）癌的顺序递减。因此，子宫颈鳞状细胞癌中PR的存在和水平被认为是分化程度的一个指标。子宫颈腺癌病例中未检测到PR。这可能解释了子宫颈腺癌对孕激素治疗反应不佳的原因。患者的预后与PR或AR的存在无关，但ER含量丰富（大于或等于5 fmol/μg DNA）的病变患者的预后往往优于ER含量低（小于5 fmol/μg DNA）的病变患者。绝经前患者的预后往往优于绝经后患者。这些发现表明子宫颈癌与内分泌背景之间存在关联。
