Matsui M, Kojima O, Kawakami S, Uehara Y, Takahashi T
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Surg Today. 1992;22(5):421-5. doi: 10.1007/BF00308791.
Estrogen receptors (ER) and progesterone receptors (PgR) were immunohistologically investigated in 107 patients with gastric cancer who underwent curative resection. Both ER and PgR were detected only in the cancer cell nucleus. The ER positive rate was 27.7% for males and 31.0% for females, while the PgR positive rate was 9.2% for males and 11.9% for females. Clinicopathologically, the ER positive rate was slightly higher in young females and in cases of poorly differentiated gastric cancer. When cumulative survival rates were analyzed in relation to the presence or absence of receptors, the 10-year cumulative survival rate after surgery was significantly lower in the ER positive cases, being 15.7% cent, than in the ER negative cases, being 62.7%, and also significantly lower in the PgR positive cases, being 18.2%, than in the PgR negative cases, being 48.3%. The coexistence of ER and PgR in gastric cancer tissues suggests that the ER is physiologically active, or that ER positive gastric cancer is hormone-dependent. The poor prognosis of patients with receptor positive gastric cancer suggests that gastric cancer with these receptors is highly malignant.
对107例行根治性切除的胃癌患者进行了雌激素受体（ER）和孕激素受体（PgR）的免疫组织化学研究。ER和PgR均仅在癌细胞核中检测到。男性的ER阳性率为27.7%，女性为31.0%，而男性的PgR阳性率为9.2%，女性为11.9%。在临床病理方面，年轻女性和低分化胃癌病例的ER阳性率略高。当分析累积生存率与受体存在与否的关系时，ER阳性病例术后10年累积生存率显著低于ER阴性病例，分别为15.7%和62.7%，PgR阳性病例术后10年累积生存率也显著低于PgR阴性病例，分别为18.2%和48.3%。胃癌组织中ER和PgR的共存表明ER具有生理活性，或者ER阳性胃癌是激素依赖性的。受体阳性胃癌患者预后较差表明，具有这些受体的胃癌具有高度恶性。
