可见的光催化自由基-自由基交叉偶联反应的胺和羰基化合物:一种途径 1,2-氨基醇。
Visible Light Photocatalytic Radical-Radical Cross-Coupling Reactions of Amines and Carbonyls: A Route to 1,2-Amino Alcohols.
机构信息
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan, Hubei 430079, China.
出版信息
J Org Chem. 2016 Aug 19;81(16):7237-43. doi: 10.1021/acs.joc.6b01217. Epub 2016 Jul 20.
PMID:27385397
Abstract
An intermolecular radical-radical cross-coupling reaction of secondary and tertiary amines with aryl ketones and aldehydes has been developed using visible light photoredox catalysis. This reaction provides an efficient and straightforward approach to some useful 1,2-amino alcohols in moderate to good yields under mild conditions.
摘要
可见光光氧化还原催化实现了二级和三级胺与芳基酮和醛的分子间自由基-自由基交叉偶联反应。该反应在温和条件下以中等至良好的收率提供了一种有效且直接的方法来合成一些有用的 1,2-氨基醇。
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