Laboratory of Toxicological Research, Rodovia Raposo Tavares, University of Sorocaba, Km 92.5, Sorocaba, São Paulo State, 18023-000, Brazil.
Eur J Nutr. 2017 Oct;56(7):2255-2264. doi: 10.1007/s00394-016-1266-1. Epub 2016 Jul 7.
Functional foods can prevent/reduce the risks related to obesity. Lentinula edodes is a highly nutritious mushroom rich in protein, vitamins and minerals. Some studies have demonstrated the hypocholesterolemic effects from L. edodes in high doses, which does not represent the consumption in humans. We evaluated ingestion of a realistic dose of L. edodes associated with a high-fat diet (HFD) on hematologic, biochemical and oxidative stress parameters.
Eighteen male Wistar rats were divided into three groups: control (normal diet); HFD; and HFD + L. edodes (100 mg/kg/day). After 30 days, blood was collected. Biochemical and hematologic parameters were analyzed, as well as oxidative stress biomarkers.
The HFD increased levels of total cholesterol and triglycerides. Lentinula edodes reduced these parameters significantly to concentrations found in the control group. The HFD increased levels of alanine transaminase and aspartate transaminase (markers of liver damage). Lentinula edodes returned the levels of these enzymes to normal levels and normalized serum levels of urea (which were also increased owing to consumption of the HFD). Lentinula edodes reduced levels of urea and glucose. Lipid peroxidation was increased in rats receiving the HFD, and L. edodes reduced malondialdehyde levels, thereby preventing oxidation of fatty acids.
Lentinula edodes was shown to have hypolipidemic, hypoglycemic, hepatoprotective and renoprotective features in doses that are suitable for humans.
功能性食品可以预防/降低与肥胖相关的风险。香菇是一种营养丰富的蘑菇，富含蛋白质、维生素和矿物质。一些研究表明，香菇在高剂量下具有降胆固醇作用，但这并不代表人类的实际摄入量。我们评估了摄入实际剂量的香菇并结合高脂肪饮食（HFD）对血液学、生化和氧化应激参数的影响。
将 18 只雄性 Wistar 大鼠分为三组：对照组（正常饮食）；HFD 组；HFD+香菇（100mg/kg/天）组。30 天后采集血液。分析生化和血液参数以及氧化应激生物标志物。
HFD 增加了总胆固醇和甘油三酯的水平。香菇显著降低了这些参数，使其恢复到对照组水平。HFD 增加了丙氨酸转氨酶和天冬氨酸转氨酶（肝损伤标志物）的水平。香菇使这些酶的水平恢复正常，并使因 HFD 摄入而升高的血清尿素水平正常化。香菇降低了尿素和葡萄糖的水平。HFD 组的脂质过氧化增加，香菇降低了丙二醛水平，从而防止了脂肪酸的氧化。
香菇在适合人类的剂量下具有降血脂、降血糖、保肝和护肾作用。
