Alzoubi Mohammed R, Aldomi Al-Domi Hayder
Department of Nutrition and Food Technology, Faculty of Agriculture, The University of Jordan, 11942 Amman, Jordan.
Diabetes Metab Syndr. 2017 Oct-Dec;11(4):297-304. doi: 10.1016/j.dsx.2016.06.024. Epub 2016 Jun 23.
Obesity and Obstructive sleep Apnea (OSA) seems to bi-directional; obesity itself increases the risk of OSA, but on the other hand, OSA may also predispose the individuals to weight gain, both obesity and OSA share a common immune-metabolic link state which have a synergistic effect on the activation of inflammation, insulin resistance and dyslipidemia, and cardiovascular disease. The Immune-metabolic role of omega-3 fatty acids Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA), which capable of modulating both metabolic and immune process, which may decrease pro-inflammatory cytokines, insulin resistance, and dyslipidemia. To date, no study in humans suffering from OSA and omega-3 fatty acids has been performed. Hence, the objective of this review aimed to discussing the link between immune-metabolic consequences related to intermittent hypoxia and does Omega-3 fatty acids a therapeutic treatment for co-morbidity associated with obstructive sleep apnea.
肥胖与阻塞性睡眠呼吸暂停（OSA）似乎存在双向关系；肥胖本身会增加患OSA的风险，但另一方面，OSA也可能使个体易于体重增加，肥胖和OSA都共享一种共同的免疫代谢关联状态，这种状态对炎症激活、胰岛素抵抗、血脂异常和心血管疾病具有协同作用。ω-3脂肪酸二十二碳六烯酸（DHA）和二十碳五烯酸（EPA）的免疫代谢作用能够调节代谢和免疫过程，这可能会减少促炎细胞因子、胰岛素抵抗和血脂异常。迄今为止，尚未对患有OSA的人类与ω-3脂肪酸进行研究。因此，本综述的目的旨在讨论与间歇性缺氧相关的免疫代谢后果之间的联系，以及ω-3脂肪酸是否是阻塞性睡眠呼吸暂停相关合并症的一种治疗方法。
