Haight J S, Gardiner G W
Department of Otolaryngology, St. Michael's Hospital, Toronto, Ontario, Canada.
J Otolaryngol. 1989 Jun;18(4):144-50.
Posterior rhinometric measurements of nasal resistance were conducted on two groups of patients with perennial rhinitis: those whose symptom of nasal stuffiness responded to a topical steroid spray and those in whom it did not. The anterior ends of the inferior turbinates in 48 patients were treated with either cryosurgery or cautery, and in half of the subjects the erectile tissue of the septum was also thermally ablated. Measurements were made before and 10-16 weeks after therapy. It is concluded from statistical comparison that there is no benefit to treating the septum, and that cryosurgery is more effective in those whose symptoms respond to topical steroids, while cautery works better in those who do not. Histology showed no change in the capacitance vessels (sinusoids) after either modality, and xylometazoline caused a marked decrease in nasal resistance, suggesting that vascular smooth muscle function was intact. Irrespective of the change in airway resistance, most subjects felt that there had been an improvement. The mechanism is discussed.
一组是鼻塞症状对局部类固醇喷雾剂有反应的患者，另一组是鼻塞症状对此无反应的患者。对48例患者的下鼻甲前端进行了冷冻手术或烧灼治疗，并且在一半的受试者中，鼻中隔的勃起组织也进行了热消融。在治疗前和治疗后10 - 16周进行了测量。通过统计学比较得出的结论是，治疗鼻中隔没有益处，冷冻手术对症状对局部类固醇有反应的患者更有效，而烧灼术对症状无反应的患者效果更好。组织学显示，两种治疗方式后容量血管（血窦）均无变化，且赛洛唑啉使鼻阻力显著降低，提示血管平滑肌功能完好。无论气道阻力如何变化，大多数受试者都感觉病情有改善。对其机制进行了讨论。
