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[妊娠期高血压疾病:心血管系统长期预后]

[Hypertensive disorders during pregnancy: Cardiovascular long-term outcomes].

作者信息

Alvarez-Alvarez B, Martell-Claros N, Abad-Cardiel M, García-Donaire J A

机构信息

Centro de Salud Andrés Mellado, Madrid, España.

Unidad de Hipertensión, Servicio de Medicina Interna, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, España.

出版信息

Hipertens Riesgo Vasc. 2017 Apr-Jun;34(2):85-92. doi: 10.1016/j.hipert.2016.06.002. Epub 2016 Jul 6.

DOI:10.1016/j.hipert.2016.06.002
PMID:27394656
Abstract

Pregnancy-induced hypertension (PIH) induces maternal and fetal damage, but it can also be the beginning of future metabolic and vascular disorders. The relative risk of chronic hypertension after PIH is between 2.3 and 11, and the likelihood of subsequent development of type 2 diabetes is multiplied by 1.8. Women with prior preeclampsia/eclampsia have a twofold risk of stroke and a higher frequency of arrhythmias and hospitalization due to heart failure. Furthermore, a tenfold greater risk for long-term chronic kidney disease is observed as well. The relative risk of cardiovascular death is 2.1 times higher compared to the group without pregnancy-induced hypertension problems, although the risk is between 4 and 7 times higher in preterm birth associated with gestational hypertension or pre-existing hypertension The postpartum period is a great opportunity to intervene on lifestyle, obesity, make an early diagnosis of chronic hypertension and DM and provide the necessary treatments to prevent cardiovascular complications in women.

摘要

妊娠期高血压疾病(PIH)会导致母婴损伤,但它也可能是未来代谢和血管疾病的开端。PIH后发生慢性高血压的相对风险在2.3至11之间,随后发生2型糖尿病的可能性会增加1.8倍。既往有子痫前期/子痫的女性患中风的风险加倍,心律失常和因心力衰竭住院的频率更高。此外,长期慢性肾病的风险也会高出10倍。与没有妊娠期高血压问题的人群相比,心血管死亡的相对风险高出2.1倍,尽管在与妊娠高血压或既往高血压相关的早产中,该风险高出4至7倍。产后期是干预生活方式、肥胖问题、早期诊断慢性高血压和糖尿病,并提供必要治疗以预防女性心血管并发症的绝佳时机。

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2
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Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia.与精神压力或呼吸暂停相比,近期患有先兆子痫的女性在进行握力运动时血压反应增强。
Am J Physiol Heart Circ Physiol. 2024 Jul 1;327(1):H140-H154. doi: 10.1152/ajpheart.00020.2024. Epub 2024 May 3.
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The joint effect of gestational diabetes mellitus and hypertension contribute to higher risk of diabetes mellitus after delivery: a nationwide population-based study.
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BMC Pregnancy Childbirth. 2023 Jul 26;23(1):539. doi: 10.1186/s12884-023-05829-6.
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The Risk and Clinical Treatment of Hypertensive Diseases in Pregnant Women.孕妇高血压疾病的风险与临床治疗。
Biomed Res Int. 2022 Sep 5;2022:8480106. doi: 10.1155/2022/8480106. eCollection 2022.
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Angiotensin 1-7 and its analogue decrease blood pressure but aggravate renal damage in preeclamptic mice.血管紧张素 1-7 及其类似物可降低血压,但可加重子痫前期小鼠的肾脏损伤。
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Exp Physiol. 2022 Feb;107(2):175-182. doi: 10.1113/EP090177. Epub 2022 Jan 9.
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Clin Sci (Lond). 2021 May 14;135(9):1083-1101. doi: 10.1042/CS20200894.
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