Ma Guangyong, Yasunaga Jun-Ichirou, Matsuoka Masao
Laboratory of Virus Control, Institute for Virus Research, Kyoto University, Kyoto, Japan.
Retrovirology. 2016 Mar 15;13:16. doi: 10.1186/s12977-016-0249-x.
Human T cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus responsible for the development of adult T-cell leukemia (ATL). Although HTLV-1 harbors an oncogene, tax, that transforms T cells in vitro and induces leukemia in transgenic mice, tax expression is frequently disrupted in ATL, making the oncogenesis of ATL a bit mysterious. The HTLV-1 bZIP factor (HBZ) gene was discovered in 2002 and has been found to promote T-cell proliferation and cause lymphoma in transgenic mice. Thus HBZ has become a novel hotspot of HTLV-1 research. This review summarizes the current findings on HBZ with a special focus on its potential links to the oncogenesis of ATL. We propose viewing HBZ as a critical contributing factor in ATL development.
人类T细胞白血病病毒1型（HTLV-1）是一种致癌逆转录病毒，可导致成人T细胞白血病（ATL）的发生。尽管HTLV-1含有一个癌基因tax，该基因在体外可转化T细胞并在转基因小鼠中诱发白血病，但tax表达在ATL中常常被破坏，这使得ATL的肿瘤发生略显神秘。HTLV-1碱性亮氨酸拉链因子（HBZ）基因于2002年被发现，并且已发现在转基因小鼠中可促进T细胞增殖并引发淋巴瘤。因此，HBZ已成为HTLV-1研究的一个新热点。本综述总结了目前关于HBZ的研究结果，特别关注其与ATL肿瘤发生的潜在联系。我们建议将HBZ视为ATL发展的关键促成因素。
