Gao Huile
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu, China.
Curr Drug Metab. 2016;17(8):731-736. doi: 10.2174/1389200217666160630203600.
Tumor microenvironment is so complex that involves in many factors of tumor. Although enhanced permeability and retention effect is a main driving force of tumor targeted nanoparticles, the tumor microenvironment greatly affects the delivery efficiency of nanoparticles.
A careful search of the scientific database was performed to find the tumor microenvironment related papers. Then the papers were concluded and reviewed.
In tumor, elevated interstitial fluid pressure, abnormal tumor vasculature, dense tumor extracellular matrix and elevated solid stress considerably hinder the extravasation and intratumor penetration of nanoparticles. Therefore, shaping the tumor microenvironment could improve nanoparticle delivery, including vascular normalization, vasculature promotion therapy, lymph normalization, reducing tumor stroma components, elevating blood pressure, elevating receptor expression, cell cycle arrest and priming by cytotoxic therapy.
Shaping the tumor microenvironment could considerably enhance the nanoparticles delivery.
肿瘤微环境非常复杂，涉及肿瘤的许多因素。尽管增强渗透与滞留效应是肿瘤靶向纳米颗粒的主要驱动力，但肿瘤微环境极大地影响纳米颗粒的递送效率。
对科学数据库进行仔细检索以查找与肿瘤微环境相关的论文。然后对这些论文进行总结和综述。
在肿瘤中，升高的间质液压力、异常的肿瘤血管、致密的肿瘤细胞外基质和升高的固体应力显著阻碍纳米颗粒的渗出和肿瘤内渗透。因此，塑造肿瘤微环境可改善纳米颗粒递送，包括血管正常化、血管生成促进疗法、淋巴正常化、减少肿瘤基质成分、升高血压、升高受体表达、细胞周期阻滞以及通过细胞毒性疗法进行预处理。
塑造肿瘤微环境可显著增强纳米颗粒的递送。
